Sun Jian-hua, Li Jing, Huang Ping, Bu Jun, Xu Zheng-min, Li Jin, Shen Xiao-ming
Neonatal Intensive Care Unit, and ENT Department, Shanghai Second Medical University affiliated Shanghai Xinhua Hospital, Children's Medical Center (SCMC), Shanghai 200127, China.
Zhonghua Er Ke Za Zhi. 2003 May;41(5):357-9.
Hearing impairment or loss is a common disorder at birth. Many perinatal conditions may also cause hearing impairment. The present study aimed at investigating the incidence and morbidity of hearing impairment in critically ill neonates with high risk factors in neonatal intensive care unit (NICU).
Patients were evaluated using the auditory brain-stem response (ABR) to detect hearing impairment or loss in 248 neonates stabilized or before discharge from the NICU during the period from Dec. 1999 to Aug. 2001 in SCMC. In this article, high risk factors of hearing loss included severe asphyxia, hyperbilirubinemia and very low birth weight, persistent pulmonary hypertension or on a ventilator, exposed to ototoxic medications such as aminoglycosides and diuretics, a family history of hearing loss, meningitis and craniofacial anomalies, etc. Screening test was performed with a 70 dB (SPL) hearing level click stimulus to each ear.
Seventy-two newborns had detectable hearing impairment in all the patients studied, the incidence of hearing impairment was 29.03%. Among them 3 cases had serious hearing loss. Twenty cases were among the 50 asphyxiated newborns (40.0%); 24 were from the 91 neonates with hyperbilirubinemia (26.37%); 15 were from the 44 premature infant group (34.09%), three of 4 premature cases with birth weight less than 1 500 g had hearing impairment. Six cases were among the 15 newborns who used mechanical ventilation (40.0%); 19 cases were among the 46 newborns who received ototoxic agents (41.30%).
Critically ill neonates with some specific high risk factors had a significantly high incidence of hearing impairment. Early hearing screening is necessary for neonates who are discharged from NICU.
听力障碍或失聪是一种常见的出生时即有的病症。许多围产期状况也可能导致听力障碍。本研究旨在调查新生儿重症监护病房(NICU)中具有高危因素的危重新生儿听力障碍的发生率和发病率。
在1999年12月至2001年8月期间,于南方医科大学珠江医院对248例在NICU病情稳定或即将出院的新生儿,使用听性脑干反应(ABR)进行评估以检测听力障碍或失聪。在本文中,听力损失的高危因素包括重度窒息、高胆红素血症、极低出生体重、持续性肺动脉高压或使用呼吸机、接触耳毒性药物如氨基糖苷类和利尿剂、听力损失家族史、脑膜炎和颅面畸形等。对每只耳朵使用70分贝(声压级)听力水平的短声刺激进行筛查测试。
在所研究的所有患者中,72例新生儿存在可检测到的听力障碍,听力障碍发生率为29.03%。其中3例有严重听力损失。20例在50例窒息新生儿中(40.0%);24例来自91例高胆红素血症新生儿(26.37%);15例来自44例早产婴儿组(34.09%),4例出生体重小于1500克的早产病例中有3例有听力障碍。6例在15例使用机械通气的新生儿中(40.0%);19例在46例接受耳毒性药物治疗的新生儿中(41.30%)。
具有某些特定高危因素的危重新生儿听力障碍发生率显著较高。对从NICU出院的新生儿进行早期听力筛查很有必要。