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对于复发性主动脉弓梗阻,手术干预是否仍然适用?

Is surgical intervention still indicated in recurrent aortic arch obstruction?

作者信息

Zoghbi Joy, Serraf Alain, Mohammadi Siamak, Belli Emré, Lacour Gayet François, Aupecle B, Losay J, Petit J, Planché Claude

机构信息

Marie Lannelongue Hospital, Paris-Sud University, France.

出版信息

J Thorac Cardiovasc Surg. 2004 Jan;127(1):203-12. doi: 10.1016/s0022-5223(03)01290-x.

Abstract

BACKGROUND

Introduction of balloon dilatation has become the standard treatment for recurrent aortic arch obstruction and has changed the therapeutic approach to patients with this disorder.

OBJECTIVES

Whether all patients with recurrent aortic arch obstruction are candidates for balloon dilatation remains unanswered. In addition, only few reports have tried to compare the results between patients undergoing balloon dilatation or redo operations.

METHODS

Since 1983, 97 patients underwent reintervention for recurrent aortic arch obstruction (42 dilations and 55 reoperations). Eight had immediate unsuccessful dilatation and were shifted to the surgical group (n = 63). The median age at reintervention was 21.7 months (10 days-45 years), and the median delay was 13.6 months (7 days-17 years). Anatomy of the aortic arch oriented the surgical approach to treat arch hypoplasia. It could be performed through a left thoracotomy in 52 patients, with extended end-to-end anastomosis in 34 patients, subclavian flap repair in 9 patients, conduit insertion in 6 patients, and patch enlargement in 3 patients. More recently, an anterior approach with cardiopulmonary bypass without circulatory arrest was applied to enlarge the patch in all the aortic arches.

RESULTS

There was one early death in the surgical intervention group and 2 late deaths in the dilation group. Major complications and recurrence were higher in the dilated group (4 vs 0, P <.01, and 14 vs 5, P <.0004, respectively). At a mean follow-up of 11.8 +/- 4.1 years in the surgical intervention group and 7.5 +/- 2.5 years in the dilated group, systemic hypertension was normalized in all but 5 patients in the surgical intervention group and 6 patients in the dilated group.

CONCLUSION

Reoperation for recurrent aortic arch obstruction can be performed safely, with low rates of mortality and morbidity. This approach should be considered versus balloon angioplasty, especially in patients older than 4 years and in the presence of aortic arch hypoplasia.

摘要

背景

球囊扩张术的引入已成为复发性主动脉弓梗阻的标准治疗方法,并改变了对该疾病患者的治疗方式。

目的

并非所有复发性主动脉弓梗阻患者都适合球囊扩张术,这一问题仍未得到解答。此外,仅有少数报告尝试比较接受球囊扩张术或再次手术的患者的结果。

方法

自1983年以来,97例患者因复发性主动脉弓梗阻接受了再次干预(42例扩张术和55例再次手术)。8例球囊扩张术即刻失败,转而进入手术组(n = 63)。再次干预时的中位年龄为21.7个月(10天至45岁),中位延迟时间为13.6个月(7天至17年)。主动脉弓的解剖结构决定了治疗弓发育不全的手术方式。52例患者可通过左胸切口进行手术,其中34例行端端吻合术,9例行锁骨下瓣修补术,6例行管道植入术,3例行补片扩大术。最近,在所有主动脉弓中均采用了在体外循环下不阻断循环的前路方法来扩大补片。

结果

手术干预组有1例早期死亡,扩张术组有2例晚期死亡。扩张术组的主要并发症和复发率更高(分别为4例对0例,P <.01;14例对5例,P <.0004)。手术干预组平均随访11.8±4.1年,扩张术组平均随访7.5±2.5年,手术干预组除5例患者外,扩张术组除6例患者外,所有患者的系统性高血压均恢复正常。

结论

复发性主动脉弓梗阻再次手术可安全进行,死亡率和发病率较低。应考虑采用这种方法而非球囊血管成形术,尤其是对于4岁以上且存在主动脉弓发育不全的患者。

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