苯甲醇与乙醇之间的行为和酶促相互作用。
Behavioral and enzymatic interactions between benzyl alcohol and ethanol.
作者信息
Messiha F S, Pasi A, Morniroli G
机构信息
School of Medicine, Texas Tech University Health Sciences Center, Lubbock 79409.
出版信息
Pharmacol Biochem Behav. 1992 Dec;43(4):1071-4. doi: 10.1016/0091-3057(92)90483-v.
Acute IP injection of benzyl alcohol but not benzaldehyde (0.5 g/kg) caused aversion to voluntary drinking of 5% ethanol solution by male rats with preference to ethanol. Benzyl alcohol noncompetitively inhibited hepatic alcohol dehydrogenase of rats maintained for a short term on 5% ethanol compared to control. The results suggest an adverse interaction between benzyl alcohol and ethanol underlying the observed aversion to ethanol.
急性腹腔注射苯甲醇而非苯甲醛（0.5克/千克）会导致偏好乙醇的雄性大鼠厌恶自愿饮用5%乙醇溶液。与对照组相比，苯甲醇非竞争性抑制短期饮用5%乙醇的大鼠的肝脏乙醇脱氢酶。结果表明，苯甲醇和乙醇之间存在不良相互作用，这是观察到的对乙醇厌恶的潜在原因。
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