Schnur P, Espinoza M, Flores R
Department of Psychology, University of Southern Colorado, Pueblo 81001-4901.
Pharmacol Biochem Behav. 1992 Dec;43(4):979-84. doi: 10.1016/0091-3057(92)90470-z.
Locomotor activity in golden Syrian hamsters was measured following IP injections of cholecystokinin (CCK; 25 micrograms/kg) and pimozide (0.5 mg/kg), the dopamine receptor antagonist. In addition, animals were tested during either the dark or light phase of the diurnal cycle in either dark or light running wheel environments. Results indicated that CCK-elicited hypoactivity was blocked by pimozide and that the effect of CCK was evident only among animals tested during the light phase of the daily cycle. Ambient lighting conditions in the test environment did not modify the drug effects. Independently of any drug effect, locomotor activity was affected by diurnal phase and ambient lighting in the test environment. Animals were more active when tested during the dark phase than during the light phase and locomotor activity was higher under dark than under light ambient conditions. It is concluded that diurnal phase modulates CCK's effect on hamster locomotion and that CCK's effect on locomotion is mediated, in part, by dopaminergic mechanisms.
腹腔注射胆囊收缩素（CCK；25微克/千克）和多巴胺受体拮抗剂匹莫齐特（0.5毫克/千克）后，对金黄仓鼠的运动活动进行了测量。此外，在昼夜循环的黑暗或光照阶段，在黑暗或光照的跑轮环境中对动物进行测试。结果表明，匹莫齐特可阻断CCK引起的活动减少，且CCK的作用仅在每日循环光照阶段测试的动物中明显。测试环境中的环境光照条件并未改变药物作用。与任何药物作用无关，运动活动受昼夜阶段和测试环境中的环境光照影响。在黑暗阶段测试时，动物比在光照阶段更活跃，且在黑暗环境条件下的运动活动高于光照环境条件下。结论是，昼夜阶段调节CCK对仓鼠运动的影响，且CCK对运动的影响部分由多巴胺能机制介导。
