Nastri G, Cappelletti M, Cappellini M D, Bonelli N, Balzani A, Fiorelli G
II Servizio di Radiologia, Ospedale Maggiore, Milano.
Radiol Med. 1992 Nov;84(5):576-81.
A series of 8 patients affected with hemolytic beta thalassemia with intrathoracic extramedullary hematopoiesis is reviewed. All patients were studied with conventional radiologic techniques and with CT and MR imaging. There was good correlation between conventional radiology findings and MR and CT results. CT and MR imaging were useful to evaluate not only the topographic localization of the masses of extramedullary hematopoiesis, but also their functional status. On CT, masses in the active phase exhibit high density and marked enhancement after i.v. administration of contrast medium; in the remission phase, the masses are hypodense, due to fat substitution, and unenhanced. On MR images, the active phase is characterized by a relatively low signal in both T1 and T2, while in the remission phase high signal is observed in both T1 and T2. A sign is seen on MR images which is considered as pathognomonic: a peripheral ring with high signal. The use of CT and MR imaging allows detailed information on the evolution of the hemolytic disease to be obtained. These pieces of information cannot be obtained with conventional radiology, which allows, at any rate, the correct diagnosis to be made.
回顾了8例患有溶血性β地中海贫血并伴有胸内髓外造血的患者。所有患者均采用传统放射学技术以及CT和MR成像进行研究。传统放射学检查结果与MR和CT结果之间具有良好的相关性。CT和MR成像不仅有助于评估髓外造血肿块的位置，还能评估其功能状态。在CT上，活跃期的肿块表现为高密度，静脉注射造影剂后有明显强化；在缓解期，由于脂肪替代，肿块呈低密度且无强化。在MR图像上，活跃期在T1和T2加权像上均表现为相对低信号，而在缓解期T1和T2加权像上均观察到高信号。在MR图像上可见一种被认为具有特征性的征象：外周高信号环。CT和MR成像的应用能够获取有关溶血性疾病演变的详细信息。这些信息无法通过传统放射学获得，不过传统放射学无论如何都能做出正确诊断。
