P2Y12受体在血小板活化中的核心作用。
Central role of the P2Y12 receptor in platelet activation.
作者信息
Dorsam Robert T, Kunapuli Satya P
机构信息
Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA.
出版信息
J Clin Invest. 2004 Feb;113(3):340-5. doi: 10.1172/JCI20986.
Abstract
Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.
摘要
血小板活化是对血管损伤的反应，对于止血很重要。疾病状态下的血小板活化会导致血管闭塞和缺血性损伤。由二磷酸腺苷（ADP）激活的P2Y（12）受体在血小板活化中起核心作用，并且是已证明具有治疗价值的P2Y（12）受体拮抗剂的作用靶点。
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