苦瓜果实与运动对2型糖尿病小鼠血糖的抑制作用

Suppressive activity of the fruit of Momordica charantia with exercise on blood glucose in type 2 diabetic mice.

作者信息

Miura Toshihiro, Itoh Yasushi, Iwamoto Naoki, Kato Motoshi, Ishida Torao

机构信息

Department of Clinical Nutrition, Suzuka University of Medical Science, 1000-1 Kishioka, Suzuka, Mie 510-0293, Japan.

出版信息

Biol Pharm Bull. 2004 Feb;27(2):248-50. doi: 10.1248/bpb.27.248.

DOI:10.1248/bpb.27.248

PMID:14758046

Abstract

The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) with exercise was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L. (MC) with exercise reduced the blood glucose of KK-Ay mice 5 weeks after oral administration (p<0.001), and also significantly lowered the plasma insulin of KK-Ay mice under similar conditions (p<0.01). The blood glucose of MC with exercise is lower than that of MC only or exercise only 5 weeks after the administration. MC with exercise decreased blood glucose in a glucose tolerance test. These results suggest that MC with exercise is useful for type 2 diabetic cure.

摘要

在KK-Ay小鼠（一种患有2型糖尿病伴高胰岛素血症的动物模型）中研究了苦瓜（葫芦科）与运动相结合的抗糖尿病活性。苦瓜果实的水提取物（MC）与运动相结合，在口服给药5周后降低了KK-Ay小鼠的血糖（p<0.001），并且在类似条件下也显著降低了KK-Ay小鼠的血浆胰岛素水平（p<0.01）。给药5周后，运动结合MC组的血糖低于单独使用MC组或单独运动组。运动结合MC在葡萄糖耐量试验中降低了血糖。这些结果表明，运动结合MC对2型糖尿病的治疗是有用的。