Nkambo W, Anyama N G, Onegi B
Department of Pharmacy, School of Health Sciences, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Afr Health Sci. 2013 Dec;13(4):933-9. doi: 10.4314/ahs.v13i4.11.
Momordica charantia L. is a medicinal plant commonly used in the management of diabetes mellitus.
We investigated the blood glucose lowering effect of the methanolic fruit extract of the Ugandan variety of M. charantia L. in alloxan-induced diabetic albino rats.
500g of M. charantia powder were macerated in methanol and the extract administered to two groups of alloxan-induced diabetic rats. The first group received 125mg/kg, the second 375mg/kg and a third group 7mg/kg of metformin. A fourth group received 1ml normal saline. Fasting blood glucose (FBG) levels were measured at 0.5,1,2,3,5,8 and 12 hours and compared using one-way ANOVA.
There was an initial rise in FBG for 1 hour after administration of extracts followed by steep reductions. Significant reduction in FBG occurred at 2 hours for 125mg/kg of extract (-3.2%, 313±25.9 to 303±25.0mg/dL, p = 0.049), 375mg/kg of extract (-3.9%, 356±19.7 to 342±20.3mg/dL, p = 0.001), and metformin (-2.6%, 344±21.7 to 335±21.1mg/dL, p = 0.003) when compared to normal saline. The maximum percentage reduction in FBG by both extracts occurred between 3 and 12 hours post dose.
The methanolic fruit extract of M. charantia exhibits dose dependent hypoglycaemic activity in vivo.
苦瓜是一种常用于治疗糖尿病的药用植物。
我们研究了乌干达品种苦瓜果实甲醇提取物对四氧嘧啶诱导的糖尿病白化大鼠的降血糖作用。
将500克苦瓜粉末用甲醇浸渍，提取物给予两组四氧嘧啶诱导的糖尿病大鼠。第一组接受125毫克/千克，第二组接受375毫克/千克，第三组接受7毫克/千克的二甲双胍。第四组接受1毫升生理盐水。在0.5、1、2、3、5、8和12小时测量空腹血糖（FBG）水平，并使用单因素方差分析进行比较。
给药后1小时FBG最初升高，随后急剧下降。与生理盐水相比，125毫克/千克提取物（-3.2%，313±25.9至303±25.0毫克/分升，p = 0.049）、375毫克/千克提取物（-3.9%，356±19.7至342±20.3毫克/分升，p = 0.001）和二甲双胍（-2.6%，344±21.7至335±21.1毫克/分升，p = 0.003）在2小时时FBG显著降低。两种提取物使FBG降低的最大百分比出现在给药后3至12小时之间。
苦瓜果实甲醇提取物在体内表现出剂量依赖性的降血糖活性。
