Sequeira Reginald P, Al Khaja Khalid A Jassim, Damanhori Awatif H H, Mathur Vijay S
Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Bahrain.
J Eval Clin Pract. 2003 Nov;9(4):409-15. doi: 10.1046/j.1365-2753.2003.00393.x.
To determine: (i) the gender-based differences of physicians in prescribing antihypertensive drugs in the management of hypertension; (ii) the influence of patient comorbidity such as diabetes mellitus on the gender-based pattern of antihypertensive prescription, and (iii) gender-based prescription patterns among family physicians (FPs) and general practitioners (GPs).
A survey study was carried out at 15 out of 20 health centres in Bahrain during May and June 2000. A total of 3971 prescriptions, issued to 2705 patients with uncomplicated hypertension and 1266 patients with diabetic hypertension by 77 FPs (female = 54, male = 23) and 41 GPs (female = 11, male = 30), were analysed.
As monotherapy, female physicians preferred ACE inhibitors (OR: 0.82, CI: 0.68-0.98, P = 0.033). In terms of overall drug utilization (monotherapy + combination therapy): (i) male physicians preferred beta blockers (OR: 1.17, CI: 1.03-1.31, P = 0.014) and diuretics (OR: 1.15, CI: 1.00-1.32, P = 0.047), while female physicians preferred methyldopa (OR: 0.73, CI: 0.56-0.94, P = 0.019); (ii) in uncomplicated hypertension, female physicians preferred calcium channel blockers (OR: 0.83, CI: 0.69-0.99, P = 0.038) and methyldopa (OR: 0.69, CI: 0.49-0.98, P = 0.042), and (iii) in diabetic hypertension, male physicians preferred beta blockers (OR: 1.26, CI: 1.00-1.57, P = 0.047). While female FPs prescribed methyldopa more extensively (OR: 0.66, CI: 0.47-0.92, P = 0.018), male GPs prescribed beta blockers (OR: 1.28, CI: 1.00-1.62, P = 0.046).
Within the same practice setting, gender-based differences in the prescription of antihypertensive drugs were seen. Such preference for a particular class of antihypertensives was also influenced by the presence of comorbidity in patients and, to a limited extent, by the training level of primary care physicians.
确定:(i)医生在高血压管理中开具抗高血压药物方面的性别差异;(ii)患者合并症如糖尿病对基于性别的抗高血压处方模式的影响,以及(iii)家庭医生(FPs)和全科医生(GPs)之间基于性别的处方模式。
2000年5月和6月在巴林的20个健康中心中的15个进行了一项调查研究。分析了77名家庭医生(女性 = 54名,男性 = 23名)和41名全科医生(女性 = 11名,男性 = 30名)为2705例单纯性高血压患者和1266例糖尿病高血压患者开具的总共3971份处方。
作为单一疗法,女性医生更喜欢使用血管紧张素转换酶抑制剂(比值比:0.82,置信区间:0.68 - 0.98,P = 0.033)。就总体药物使用情况(单一疗法 + 联合疗法)而言:(i)男性医生更喜欢使用β受体阻滞剂(比值比:1.17,置信区间:1.03 - 1.31,P = 0.014)和利尿剂(比值比:1.15,置信区间:1.00 - 1.32,P = 0.047),而女性医生更喜欢使用甲基多巴(比值比:0.73,置信区间:0.56 - 0.94,P = 0.019);(ii)在单纯性高血压中,女性医生更喜欢使用钙通道阻滞剂(比值比:0.83,置信区间:0.69 - 0.99,P = 0.038)和甲基多巴(比值比:0.69,置信区间:0.49 - 0.98,P = 0.042),以及(iii)在糖尿病高血压中,男性医生更喜欢使用β受体阻滞剂(比值比:1.26,置信区间:1.00 - 1.57,P = 0.047)。女性家庭医生更广泛地开具甲基多巴(比值比:0.66,置信区间:0.47 - 0.92,P = 0.018),而男性全科医生开具β受体阻滞剂(比值比:1.28,置信区间:l.00 - 1.62,P = 0.046)。
在相同的执业环境中,观察到抗高血压药物处方存在性别差异。对某一类抗高血压药物的这种偏好也受到患者合并症的影响,并且在一定程度上受到初级保健医生培训水平的影响。