Ikezawa Z, Ikebe T, Ogura H, Odajima H, Kurosaka F, Komatu H, Sase K, Suga C, Sugiuchi M, Suguro H
Dept. Dermatol., Yokohama City Univ. School of Med., Japan.
Acta Derm Venereol Suppl (Stockh). 1992;176:108-12.
The clinical usefulness of a hypoallergenic rice (HRS-1) which was produced by enzymatic decomposition of the constituent proteins of original rice was evaluated in a multicentre study in 44 subjects with recalcitrant atopic dermatitis (AD), who were suspected of having rice allergy. The subjects were fed for at least 4 weeks with HRS-1 instead of eliminating both regular rice and wheat from their daily diet. The extent of overall skin lesions was expressed by using the AD affected area and severity index (ADASI). A statistically significant decrease in ADASI was observed at the 2nd and the 4th week readings and at the end of the study. A provocation test with regular rice was carried out in 5 of 44 subjects following the HRS-1 therapy. An obvious increase in ADASI was found in all of these 5 cases just after this procedure. On final evaluation, 77% of the patients tested showed 'moderate' to 'remarkable' improvement, and 59% of the patients a 'moderate' to 'remarkable' reduction in use of the steroid ointment concomitantly used for the treatment. Finally, HRS-1 was evaluated as 'useful' or 'very useful' in 69% of the subjects.
通过对原始大米组成蛋白进行酶解制备的低敏大米（HRS-1），在一项针对44名顽固性特应性皮炎（AD）患者的多中心研究中进行了评估，这些患者疑似对大米过敏。研究让这些受试者食用HRS-1至少4周，而非从日常饮食中剔除普通大米和小麦。整体皮肤损伤程度通过特应性皮炎受累面积和严重程度指数（ADASI）来表示。在第2周、第4周的读数以及研究结束时，观察到ADASI有统计学意义的下降。在44名接受HRS-1治疗的受试者中，有5人在治疗后接受了普通大米激发试验。在这一试验后，所有这5例患者的ADASI均出现明显升高。在最终评估中，77%的受试患者显示出“中度”至“显著”改善，59%的患者同时使用的用于治疗的类固醇软膏用量“中度”至“显著”减少。最后，69%的受试者将HRS-1评估为“有用”或“非常有用”。
