Ikezawa Z, Miyakawa K, Komatsu H, Suga C, Miyakawa J, Sugiyama A, Sasaki T, Nakajima H, Hirai Y, Suzuki Y
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Acta Derm Venereol Suppl (Stockh). 1992;176:103-7.
1006 patients with typical and atypical lesions of atopic dermatitis (AD) were analysed statistically. The clinical severity was closely correlated to serum IgE values and RAST (radio-allergosorbent test) positivity. The frequency of RAST-positive antigens was significantly correlated with serum IgE values (gamma = 0.712; p < 0.01). The analysis of multiple correlation between the clinical severity and each RAST score for mite, egg white and rice antigens suggested a strong contribution of rice allergy to the development of severe AD. 25 patients with severe AD and positive rice-RAST were treated by rice exclusion diet. The results were as follows: 9 cases remarkably responsive, 10 cases moderately responsive and 6 cases unresponsive. The rice-RAST titre decreased most remarkably in the 1st group. The wheat-RAST titre also decreased in the 1st, in spite of taking wheat foods every day, but increased in the 3rd. A probable role of rice allergy in severe AD in Japan is discussed.
对1006例患有特应性皮炎（AD）典型和非典型皮损的患者进行了统计学分析。临床严重程度与血清IgE值及放射变应原吸附试验（RAST）阳性密切相关。RAST阳性抗原的频率与血清IgE值显著相关（γ = 0.712；p < 0.01）。对螨、蛋清和大米抗原的临床严重程度与各RAST评分之间的多重相关性分析表明，大米过敏对重度AD的发生有很大影响。对25例重度AD且大米RAST阳性的患者采用大米排除饮食进行治疗。结果如下：9例反应显著，10例反应中等，6例无反应。第1组大米RAST滴度下降最为显著。第1组小麦RAST滴度也下降，尽管每天食用小麦食品，但第3组却升高。讨论了大米过敏在日本重度AD中的可能作用。
