Palombo D, Valenti D, Gaggiano A, Lupo M, Borin P
Department of Cardiac and Vascular Diseases, Vascular Surgery Unit, Mauriziano Hospital, Largo Turati, 62, Turin I-10128, Italy.
Eur J Vasc Endovasc Surg. 2004 Mar;27(3):324-6. doi: 10.1016/j.ejvs.2003.11.012.
The purpose of this report is to describe our early experience with a minimal extracorporeal circulation system (MECC), a compact closed heparin coated system consisting of a centrifugal pump and a membrane oxygenator, during thoracoabdominal aortic aneurysm (TAAA) repair.
Between January and December 2002 the MECC system was employed in seven consecutive patients (four TAAA type II, two TAAA type I and one TAAA type III according to the Crawford classification). In all patients distal aortic, selective renal and visceral perfusion was performed with this compact closed heparin coated system consisting of a centrifugal pump and a membrane oxygenator.
The MECC system was used in all cases with no technical malfunctions. Six out seven patients were discharged from the unit. One patient developed paraplegia after TAAA repair and died on the third post-operative day from multi-organ failure. In this case the total spinal ischaemic time was 120 min and the distal aortic perfusion pressure was <50 mmHg. No cardiac, cerebral, renal, hepatic or bleeding complications were recorded in the remaining six patients.
Our early experience with MECC during TAAA repair showed that it is feasible for distal aortic spinal and visceral selective perfusion. Further large clinical trials are required to determine the efficacy of this technique.
本报告旨在描述我们在胸腹主动脉瘤(TAAA)修复过程中使用一种微型体外循环系统(MECC)的早期经验,该系统是一种由离心泵和膜式氧合器组成的紧凑型封闭式肝素涂层系统。
在2002年1月至12月期间,连续7例患者(根据克劳福德分类法,4例为II型TAAA,2例为I型TAAA,1例为III型TAAA)使用了MECC系统。在所有患者中,均使用由离心泵和膜式氧合器组成的紧凑型封闭式肝素涂层系统进行远端主动脉、选择性肾和内脏灌注。
所有病例均使用了MECC系统,无技术故障。7例患者中有6例出院。1例患者在TAAA修复后发生截瘫,术后第3天死于多器官功能衰竭。在该病例中,脊髓总缺血时间为120分钟,远端主动脉灌注压<50 mmHg。其余6例患者未记录到心脏、脑、肾、肝或出血并发症。
我们在TAAA修复过程中使用MECC的早期经验表明,进行远端主动脉、脊髓和内脏选择性灌注是可行的。需要进一步进行大型临床试验以确定该技术的疗效。