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本文引用的文献

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Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability.微卫星不稳定的胃癌中hMLH1的突变与甲基化
World J Gastroenterol. 2003 Apr;9(4):655-9. doi: 10.3748/wjg.v9.i4.655.
2
Mitochondrial DNA mutation correlates with stage progression and prognosis in non-small cell lung cancer.
Hum Mutat. 2003 Apr;21(4):441-3. doi: 10.1002/humu.10196.
3
Detection of HBV, PCNA and GST-pi in hepatocellular carcinoma and chronic liver diseases.肝细胞癌及慢性肝病中乙肝病毒、增殖细胞核抗原和谷胱甘肽S转移酶π的检测
World J Gastroenterol. 2003 Mar;9(3):459-62. doi: 10.3748/wjg.v9.i3.459.
4
Mutations of mtDNA in renal cell tumours arising in end-stage renal disease.
J Pathol. 2003 Feb;199(2):237-42. doi: 10.1002/path.1273.
5
Effects of hydrogen peroxide on mitochondrial gene expression of intestinal epithelial cells.过氧化氢对肠上皮细胞线粒体基因表达的影响。
World J Gastroenterol. 2002 Dec;8(6):1117-22. doi: 10.3748/wjg.v8.i6.1117.
6
Mutation analysis of APC gene in gastric cancer with microsatellite instability.微卫星不稳定型胃癌中APC基因的突变分析
World J Gastroenterol. 2002 Oct;8(5):787-91. doi: 10.3748/wjg.v8.i5.787.
7
Rapid screening mitochondrial DNA mutation by using denaturing high-performance liquid chromatography.运用变性高效液相色谱法快速筛查线粒体DNA突变
World J Gastroenterol. 2002 Jun;8(3):426-30. doi: 10.3748/wjg.v8.i3.426.
8
Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagus.线粒体DNA D环区域的突变在巴雷特食管腺癌中频繁发生。
Oncogene. 2002 May 23;21(23):3780-3. doi: 10.1038/sj.onc.1205532.
9
Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer.乳腺癌体细胞线粒体DNA突变的全面扫描
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10
Clinicopathological and molecular genetic analysis of 4 typical Chinese HNPCC families.4个典型中国遗传性非息肉病性结直肠癌家系的临床病理及分子遗传学分析
World J Gastroenterol. 2001 Dec;7(6):805-10. doi: 10.3748/wjg.v7.i6.805.

中国肝细胞癌中的核DNA和线粒体DNA微卫星不稳定性

Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese.

作者信息

Fang Dian-Chun, Fang Li, Wang Rong-Quan, Yang Shi-Ming

机构信息

Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

出版信息

World J Gastroenterol. 2004 Feb 1;10(3):371-5. doi: 10.3748/wjg.v10.i3.371.

DOI:10.3748/wjg.v10.i3.371
PMID:14760760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4724920/
Abstract

AIM

To study the nuclear microsatellite instability (nMSI) at BAT26 and mitochondrial microsatellite instability (mtMSI) in the occurrence and development of hepatocellular carcinoma and the relationship between nMSI and mtMSI.

METHODS

nMSI was observed with PCR and mtMSI with PCR-SSCP in 52 cases of hepatocellular carcinoma.

RESULTS

mtMSI was detected in 11 out of the 52 cases of hepatocellular carcinoma (21.2%). Among the 11 cases of hepatocellular carcinoma with mtMSI, 7 occurred in one locus and 4 in 2 loci. The frequency of mtMSI in the 52 cases of hepatocellular carcinoma showed no correlation to sex, age, infection of hepatitis B, liver cirrhosis as well as positive AFP of the patients (P>0.05). In addition, nMSI was detected in 3 out of 52 cases of hepatocellular carcinoma (5.8%) and there was no correlation of the incidence of mtMSI to that of nMSI (P>0.05).

CONCLUSION

mtMSI may be involved in the coccurrence and development of hepatocellular carcinoma and it is independent of nMSI.

摘要

目的

研究BAT26位点的核微卫星不稳定性（nMSI）及线粒体微卫星不稳定性（mtMSI）在肝细胞癌发生发展中的情况以及nMSI与mtMSI之间的关系。

方法

采用PCR法检测52例肝细胞癌患者的nMSI，采用PCR-SSCP法检测mtMSI。

结果

52例肝细胞癌患者中，11例检测到mtMSI（21.2%）。在这11例有mtMSI的肝细胞癌患者中，7例发生在一个位点，4例发生在2个位点。52例肝细胞癌患者中mtMSI的发生率与患者的性别、年龄、乙型肝炎感染、肝硬化以及甲胎蛋白阳性与否均无相关性（P>0.05）。此外，52例肝细胞癌患者中有3例检测到nMSI（5.8%），mtMSI的发生率与nMSI的发生率无相关性（P>0.05）。

结论

mtMSI可能参与肝细胞癌的发生发展，且与nMSI无关。