Apaydin Erol S, Shabahang Shahrokh, Torabinejad Mahmoud
Loma Linda University School of Dentistry, CA, USA.
J Endod. 2004 Jan;30(1):21-4. doi: 10.1097/00004770-200401000-00004.
The purpose of this study was to compare the effect of fresh mineral trioxide aggregate (MTA) with set MTA on hard-tissue healing after periradicular surgery. The root canals of 24 mandibular premolars in four 2-yr-old beagle dogs were filled with MTA. Two weeks later the root ends of half of the samples were surgically exposed and resected to the set MTA within the canals. After exposing and resecting the other 12 root ends, they were prepared with ultrasonic instrumentation and preparations were filled with fresh MTA. After 4 months, the animals were killed. Hard-tissue healing was analyzed histomorphometrically. The results indicated that although freshly placed MTA resulted in a significantly higher incidence of cementum formation (12 of 12 versus 8 of 12, p = 0.028), there is no significant difference in the quantity of cementum or osseous healing associated with freshly placed or set MTA when used as root-end-filling material.
本研究的目的是比较新鲜矿物三氧化物凝聚体（MTA）与凝固后的MTA对根尖周手术后硬组织愈合的影响。对4只2岁比格犬的24颗下颌前磨牙的根管进行MTA充填。两周后，将一半样本的根尖手术暴露并切除至根管内凝固的MTA处。在暴露并切除另外12个根尖后，用超声器械进行预备，预备后用新鲜MTA充填。4个月后，处死动物。采用组织形态计量学方法分析硬组织愈合情况。结果表明，尽管新鲜放置的MTA导致牙骨质形成的发生率显著更高（12颗中的12颗与12颗中的8颗，p = 0.028），但当用作根尖充填材料时，新鲜放置的MTA与凝固后的MTA在牙骨质或骨愈合量方面没有显著差异。
