Pancholi Vijay, Chhatwal Gursharan S
Laboratory of Bacterial Pathogenesis, Public Health Research Institute, The International Center for Public Health, Newark 07103-3535, USA.
Int J Med Microbiol. 2003 Dec;293(6):391-401. doi: 10.1078/1438-4221-00283.
Housekeeping enzymes are ubiquitously present in almost all living beings to perform essential metabolic functions for the purpose of survival. These enzymes have been characterized in detail for many years. In recent years, there has been a number of reports indicating that some of these enzymes perform a variety of other functions. In case of many pathogens, certain enzymes play a role to enhance virulence. To perform such a function, enzymes must be located on the surface of pathogens. Although they do not have the typical signal sequence or membrane anchoring mechanisms, they do get secreted and are displayed on the surface, probably by their reassociation. Once on the surface, these enzymes interact with host components, such as fibronectin and plasminogen, or interact directly with the host cells, to trigger signal transduction and thereby enable the pathogens to colonize, persist and invade the host tissue. Therefore, certain housekeeping enzymes may act as putative virulence factors and targets for the development of new strategies to control the infection by using agents that can block their secretion and/or reassociation.
管家酶几乎普遍存在于所有生物中，以执行维持生存所必需的代谢功能。这些酶已经被详细研究多年。近年来，有许多报道表明其中一些酶还具有多种其他功能。在许多病原体中，某些酶在增强毒力方面发挥作用。为了执行这样的功能，酶必须位于病原体表面。尽管它们没有典型的信号序列或膜锚定机制，但它们确实会被分泌并展示在表面，可能是通过重新结合。一旦位于表面，这些酶就会与宿主成分（如纤连蛋白和纤溶酶原）相互作用，或直接与宿主细胞相互作用，触发信号转导，从而使病原体能够在宿主组织中定植、存活并侵入。因此，某些管家酶可能作为假定的毒力因子，成为开发新策略以控制感染的靶点，这些新策略可使用能够阻断其分泌和/或重新结合的药物。
