Misao Takahiko, Yamamoto Yosuke, Nakano Hideharu, Toyooka Shinichi, Yamane Masataka, Satoh Katashi
Department of Respiratory Disease, Kagawa Prefectural Cancer Detection Center, 587-1 Goto-cho, Takamatsu, Kagawa 761-8031, Japan.
Jpn J Thorac Cardiovasc Surg. 2004 Jan;52(1):30-2. doi: 10.1007/s11748-004-0058-3.
A 59-year-old male, whose chest X-ray showed an abnormal shadow, visited us for further study. Laboratory examination showed the elevated level for both carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) in serum, and the chest X-ray and computed tomography showed an anterior mediastinal mass. Under a diagnosis of thymic malignancy, extended thymectomy with combined resection of the pleura and pericardium was performed. Histopathological findings showed a well-differentiated adenocarcinoma of the thymus, in which CA19-9 and CEA were positive immuno-histochemically. The level of serum CA19-9 and CEA returned to normal ranges postoperatively, however, the tumor recurred in local site with re-elevation of these tumor markers at the 20th month after surgery. He died at 4th month after the first recurrence despite the intensive chemotherapy. We report an extremely rare case of primary thymic adenocarcinoma with the production of CA19-9 and CEA.
一名59岁男性，胸部X线显示有异常阴影，前来我院进一步检查。实验室检查显示血清中糖类抗原19-9（CA19-9）和癌胚抗原（CEA）水平升高，胸部X线和计算机断层扫描显示前纵隔肿块。在诊断为胸腺恶性肿瘤后，进行了扩大胸腺切除术并联合切除胸膜和心包。组织病理学检查结果显示为高分化胸腺腺癌，其中CA19-9和CEA免疫组化呈阳性。术后血清CA19-9和CEA水平恢复正常范围，但术后第20个月肿瘤在局部复发，这些肿瘤标志物再次升高。尽管进行了强化化疗，他在首次复发后第4个月死亡。我们报告了一例极为罕见的原发性胸腺腺癌伴CA19-9和CEA产生的病例。
