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胸腺原发性腺癌：一项免疫组织化学和分子研究并文献复习

Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature.

作者信息

Maghbool Maryam, Ramzi Mani, Nagel Inga, Bejarano Pablo, Siebert Reiner, Saeedzadeh Abolfazl, Daneshbod Yahya

机构信息

Department of Molecular Pathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran.

出版信息

BMC Clin Pathol. 2013 May 31;13(1):17. doi: 10.1186/1472-6890-13-17.

DOI:10.1186/1472-6890-13-17
PMID:23725376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3672093/
Abstract

BACKGROUND

Primary adenocarcinoma of thymus is extremely rare.

CASE PRESENTATION

This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32.

CONCLUSION

This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors.

摘要

背景

原发性胸腺腺癌极为罕见。

病例介绍

这是一例胸腺原发性腺癌，具有肠化生及局灶性黏液分泌。该肿瘤伴有胸腺囊肿。通过免疫组化染色，CDX-2、CK20、绒毛蛋白、MOC31呈阳性，CK7呈局灶性阳性，证实为肠化生。阵列比较基因组杂交（CGH）分析显示出复杂的染色体失衡模式，包括6号染色体区域6p21.32的HLA位点纯合缺失。

结论

这种罕见肿瘤与其他已研究的胸腺上皮肿瘤表现出相似的基因畸变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e700/3672093/19e1d8d63125/1472-6890-13-17-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e700/3672093/19e1d8d63125/1472-6890-13-17-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e700/3672093/19e1d8d63125/1472-6890-13-17-1.jpg

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2
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Gen Thorac Cardiovasc Surg. 2010 Sep;58(9):488-91; discussion 491-2. doi: 10.1007/s11748-009-0580-4. Epub 2010 Sep 22.
3
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4
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5
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6
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10
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