Korcáková L, Holub M
Allerg Immunol (Leipz). 1977;23(4):287-94.
The action of "lymph node activating factor" (present in supernatants from 4hr cultures of allogeneic lymphocytes) on the lymph nodes of athymic nu/nu mice, nu/+ hybrids and euthymic BALB/c mice was studied. An increase in lymph node weight, cellularity and changes in lymph node morphology, i.e. an increase of the dense lymphatic tissue of the cortex and paracortex and appearance of follicles with light centers, were found in all mice. Lymphocyte activation evaluated by the presence of lymphocytes with RNA synthesizing nucleoli occurred only in nu/nu mice and nu/+ hybrids. Marked changes in lymph node morphology found in nu/nu homozygotes suggest relation of the lymph node activating factor to mediators acting directly on B cells.
研究了“淋巴结激活因子”（存在于同种异体淋巴细胞4小时培养上清液中）对无胸腺裸鼠（nu/nu）、杂合子（nu/+）和正常胸腺的BALB/c小鼠淋巴结的作用。在所有小鼠中均发现淋巴结重量增加、细胞增多以及淋巴结形态改变，即皮质和副皮质的致密淋巴组织增加，出现有亮中心的滤泡。通过具有RNA合成核仁的淋巴细胞的存在来评估的淋巴细胞激活仅发生在裸鼠（nu/nu）和杂合子（nu/+）中。在纯合裸鼠（nu/nu）中发现的淋巴结形态的显著变化表明淋巴结激活因子与直接作用于B细胞的介质有关。
