York Jackie R, Landers Susan, Kirby Russell S, Arbogast Patrick G, Penn John S
Department of Neonatology, Vanderbilt University, Nashville, TN 37232, USA.
J Perinatol. 2004 Feb;24(2):82-7. doi: 10.1038/sj.jp.7211040.
To determine the influence of arterial oxygen fluctuation on development of threshold ROP.
Retrospective study of 231 infants, < or =1500 g birth weight, who were admitted to Arkansas Children's Hospital NICU from January 1993 to June 1995. Fluctuation in partial pressure of dissolved arterial oxygen (PaO(2)) was expressed as coefficient of variation (CoV) for each infant. We investigated the relationship between CoV at three intervals and the risk of developing threshold ROP.
The odds ratio (OR) of developing threshold ROP versus prethreshold ROP or less associated with a 10% increase in the CoV during the first 5 days of oxygen therapy was 1.44, and during the first 10 days was 1.51. When analysis was restricted to infants receiving 30 days of therapy, the OR during the first 5 days of therapy was 1.67, during the first 10 days was 1.82, and during days 11-30 was 1.68.
Very-low-birth-weight infants experiencing fluctuating PaO(2) are at higher risk of threshold ROP.
确定动脉血氧波动对阈值ROP发展的影响。
对1993年1月至1995年6月入住阿肯色州儿童医院新生儿重症监护病房的231例出生体重≤1500g的婴儿进行回顾性研究。溶解动脉血氧分压（PaO₂）的波动以每个婴儿的变异系数（CoV）表示。我们研究了三个时间段的CoV与发生阈值ROP风险之间的关系。
在氧疗的前5天，CoV增加10%与发生阈值ROP相对于阈值前ROP或更低的比值比（OR）为1.44，在前10天为1.51。当分析仅限于接受30天治疗的婴儿时，治疗前5天的OR为1.67，前10天为1.82，第11 - 30天为1.68。
经历PaO₂波动的极低出生体重婴儿发生阈值ROP的风险更高。
