Razak Fathilah Abdul, Rahim Zubaidah Haji Abd
Department of Oral Biology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
J Oral Sci. 2003 Dec;45(4):201-6. doi: 10.2334/josnusd.45.201.
The aqueous extracts of Piper betle and Psidium guajava were prepared and tested for their anti-adherence effect on the adhesion of early plaque settlers (Strep. mitis, Strep. sanguinis and Actinomyces sp.). The saliva-coated glass surfaces were used to simulate the pellicle-coated enamel surface in the oral cavity. Our results showed that the anti-adherence activities of Piper betle and Psidium guajava extracts towards the bacteria were different between the bacterial species. Psidium guajava was shown to have a slightly greater anti-adherence effect on Strep. sanguinis by 5.5% and Actinomyces sp. by 10% and a significantly higher effect on Strep. mitis (70%) compared to Piper betle. The three bacterial species are known to be highly hydrophobic, and that hydrophobic bonding seemed to be an important factor in their adherence activities. It is therefore suggested that the plant extracts, in expressing their anti-adherence activities, could have altered the hydrophobic nature of the bonding between the bacteria and the saliva-coated glass surfaces.
制备了蒌叶和番石榴的水提取物，并测试了它们对早期菌斑定植菌（缓症链球菌、血链球菌和放线菌属）黏附的抗黏附作用。用涂有唾液的玻璃表面模拟口腔中覆盖有获得性膜的牙釉质表面。我们的结果表明，蒌叶和番石榴提取物对不同细菌种类的抗黏附活性不同。与蒌叶相比，番石榴对血链球菌的抗黏附作用略强5.5%，对放线菌属的抗黏附作用强10%，对缓症链球菌的抗黏附作用显著更高（70%）。已知这三种细菌具有高度疏水性，疏水键似乎是它们黏附活性的一个重要因素。因此，有人认为植物提取物在发挥其抗黏附活性时，可能改变了细菌与涂有唾液的玻璃表面之间结合的疏水性质。
