Kelly Cynthia M, Wilkins Ross M
Institute for Limb Preservation at Presbyterian-St. Luke's Medical Center, Denver, Colo, USA.
Orthopedics. 2004 Jan;27(1 Suppl):s131-5. doi: 10.3928/0147-7447-20040102-11.
The treatment of benign bone lesions can be challenging due to the limited quantity of autogenous graft available for harvest and grafting of the defect. The use of an injectable calcium bone graft substitute, Minimally-Invasive Injectable Graft (MIIG) (Wright Medical Technology, Inc, Arlington, Tenn), material for treatment of these bone lesions is advantageous. Calcium sulfate has a long-standing history in the treatment of bone voids secondary to trauma, infection, or neoplastic processes. Minimally-Invasive Injectable Graft injectable calcium sulfate graft may be injected into surgically created osseous defects or bone defects secondary to traumatic injury. After hardening, the paste acts as a temporary intraosseous support through which internal fixation may be placed. Fifteen patients with benign space-occupying lesions were treated with curettage and grafting with an injectable, surgical-grade, calcium sulfate bone graft substitute. Bone healing was assessed postoperatively and defined as resorption of the bone graft substitute material and replacement with new bone formation. The grafted defects in 14 of the 15 patients showed complete incorporation of the graft material at an average of 8 weeks. One patient required incision and drainage for a deep infection 5 weeks postoperatively. The average follow-up was 6 months (range: 3-15 months), and Musculoskeletal Tumor Society functional outcome scores averaged 83%. This injectable, minimally invasive graft material is easy to use, provides a temporary structural support when grafting bone defects, and results in predictable rapid bone healing.
由于可用于采集和移植骨缺损的自体骨数量有限，良性骨病变的治疗颇具挑战性。使用可注射硫酸钙骨移植替代物——微创可注射移植物（MIIG）（美国田纳西州阿灵顿市Wright Medical Technology公司）来治疗这些骨病变具有优势。硫酸钙在治疗创伤、感染或肿瘤性病变继发的骨缺损方面有着悠久的历史。微创可注射移植物可注射硫酸钙移植物可注入手术造成的骨缺损或创伤性损伤继发的骨缺损中。硬化后，糊剂可作为一种临时的骨内支撑物，通过它可进行内固定。15例患有良性占位性病变的患者接受了刮除术，并使用可注射的外科级硫酸钙骨移植替代物进行移植。术后对骨愈合情况进行评估，骨愈合定义为骨移植替代材料的吸收以及被新骨形成所替代。15例患者中有14例的移植骨缺损在平均8周时显示移植材料完全融合。1例患者在术后5周因深部感染需要切开引流。平均随访时间为6个月（范围：3 - 15个月），肌肉骨骼肿瘤学会功能结果评分平均为83%。这种可注射的微创移植材料易于使用，在移植骨缺损时提供临时的结构支撑，并能带来可预测的快速骨愈合。
