Urban Robert M, Turner Thomas M, Hall Deborah J, Infanger Susan I, Cheema Naveed, Lim Tae-Hong, Richelsoph Kelly
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Ill, USA.
Orthopedics. 2004 Jan;27(1 Suppl):s155-9. doi: 10.3928/0147-7447-20040102-16.
The addition of a plasticizer to synthetic bone graft substitutes can improve handling characteristics, injectability, and the ability to uniformly fill defects. Restoration of large medullary bone defects using an injectable calcium sulfate-based putty using hydroxypropylmethylcellose as the plasticizer was compared to conventional calcium sulfate paste in a canine model. Beginning 2 weeks following implantation, serial clinical and specimen radiographs demonstrated a similar progressive resorption of the implanted materials and replacement with new bone for both the putty and paste forms of calcium sulfate. The area fraction of new bone and remaining implant material in bone defects treated with the putty were not significantly different from defects treated with conventional calcium sulfate paste after 13 and 26 weeks. In addition to its handling characteristics, the putty was biocompatible and as effective as conventional calcium sulfate paste in achieving substantial bony restoration of a large, critical-size bone defect.
在合成骨移植替代物中添加增塑剂可以改善其操作特性、可注射性以及均匀填充缺损的能力。在犬类模型中，将使用羟丙基甲基纤维素作为增塑剂的可注射硫酸钙基油灰用于修复大型髓腔骨缺损，并与传统硫酸钙糊剂进行比较。植入后2周开始，系列临床和标本X线片显示，硫酸钙油灰和糊剂形式的植入材料均有类似的逐渐吸收，并被新骨替代。在13周和26周后，用该油灰治疗的骨缺损中新骨和剩余植入材料的面积分数与用传统硫酸钙糊剂治疗的缺损无显著差异。除操作特性外，该油灰具有生物相容性，在实现大型临界尺寸骨缺损的实质性骨修复方面与传统硫酸钙糊剂同样有效。
