Ezaki M, Iwami M, Yamashita M, Komori T, Umehara K, Imanaka H
Exploratory Research Laboratory, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Appl Environ Microbiol. 1992 Dec;58(12):3879-82. doi: 10.1128/aem.58.12.3879-3882.1992.
Production of biphenomycin A by Streptomyces griseorubiginosus 43708 was stimulated by a mixed culture with a partner strain, Pseudomonas maltophilia 1928. This stimulatory effect on biphenomycin A accumulation by the mixed culture was caused by the enzyme activity which strain 1928 possessed. It is suggested that in a mixed culture strain 43708 produces a precursor of biphenomycin A in culture broth and that strain 1928 converts the precursor to biphenomycin A.
灰色红链霉菌43708与伴生菌株嗜麦芽窄食单胞菌1928混合培养时，可刺激其产生双苯霉素A。混合培养对双苯霉素A积累的这种刺激作用是由菌株1928所具有的酶活性引起的。有人认为，在混合培养中，菌株43708在培养液中产生双苯霉素A的前体，而菌株1928则将该前体转化为双苯霉素A。
