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伴有凝血病的血管瘤：对泼尼松持续有效。

Haemangioma with coagulopathy: sustained response to prednisone.

作者信息

Evans J, Batchelor A D, Stark G, Uttley W S

出版信息

Arch Dis Child. 1975 Oct;50(10):809-12. doi: 10.1136/adc.50.10.809.

DOI:10.1136/adc.50.10.809
PMID:147646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1545680/
Abstract

Two cases of giant haemangioma with thrombocytopenia are described. A satisfactory and sustained response to prednisone was achieved in respect of both coagulation abnormalities and tumour size. It is proposed that prednisone is effective by enhancement of thrombosis and reduction of fibrinolysis within the tumour, thus promoting a natural form of resolution. It is suggested that prednisone therapy should be first-choice treatment of complicated haemangiomas.

摘要

本文描述了两例伴有血小板减少症的巨大血管瘤病例。泼尼松对凝血异常和肿瘤大小均取得了满意且持续的疗效。有人提出，泼尼松的作用机制是增强肿瘤内的血栓形成并减少纤维蛋白溶解，从而促进一种自然的消退形式。有人认为泼尼松疗法应作为复杂性血管瘤的首选治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/1545680/e2f64180de1e/archdisch00836-0066-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/1545680/8899ebbc5431/archdisch00836-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/1545680/e2f64180de1e/archdisch00836-0066-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/1545680/8899ebbc5431/archdisch00836-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/1545680/e2f64180de1e/archdisch00836-0066-b.jpg

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Haemangioma with coagulopathy: sustained response to prednisone.伴有凝血病的血管瘤：对泼尼松持续有效。
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A case of aneurysm of the jugular and mediastinal veins--radioisotopic blood pool study of venous aneurysm.一例颈静脉及纵隔静脉瘤——静脉瘤的放射性核素血池研究
Eur J Nucl Med. 1984;9(4):196-8. doi: 10.1007/BF00251473.

本文引用的文献

1
Effect of ACTH on the erythrocyte-sedimentation rate and plasma-fibrinogen and serum-protein levels in normal persons.促肾上腺皮质激素对正常人红细胞沉降率、血浆纤维蛋白原及血清蛋白水平的影响。
Lancet. 1951 Dec 15;2(6694):1113-6. doi: 10.1016/s0140-6736(51)93025-5.
2
Thromboembolic complications associated with ACTH and cortisone therapy.与促肾上腺皮质激素和可的松治疗相关的血栓栓塞并发症。
J Am Med Assoc. 1951 Nov 3;147(10):924-6. doi: 10.1001/jama.1951.03670270014006.
3
Effects of corticosteroids on coagulation of the blood.皮质类固醇对血液凝固的影响。
Nature. 1962 Sep 22;195:1214-5. doi: 10.1038/1951214a0.
4
Giant hemangioma with thrombocytopenia. Case report with survival and sequestration studies of platelets labeled with chromium 51.
Am J Dis Child. 1963 Feb;105:188-95.
5
The inhibition of clot lysis by corticotrophin.促肾上腺皮质激素对血块溶解的抑制作用。
Lancet. 1956 Jan 21;270(6908):136-7. doi: 10.1016/s0140-6736(56)91094-7.
6
The influence of the adrenal cortex on behavior of terminal vascular bed.肾上腺皮质对终末血管床行为的影响。
Ann N Y Acad Sci. 1953 Jul 17;56(4):626-33. doi: 10.1111/j.1749-6632.1953.tb27383.x.
7
Coagulation defects and giant cavernous hemangioma. A case study in infancy.凝血缺陷与巨大海绵状血管瘤。婴儿期的病例研究。
Am J Dis Child. 1966 Jan;111(1):71-4. doi: 10.1001/archpedi.1966.02090040107013.
8
Consumption coagulopathy in an infant with Kasabach-Merrit syndrome.患有卡萨巴赫-梅里特综合征婴儿的消耗性凝血病。
Helv Paediatr Acta. 1968 Dec;23(6):674-9.
9
Successful treatment of juvenile hemangiomas with prednisone.
J Pediatr. 1968 Mar;72(3):351-7. doi: 10.1016/s0022-3476(68)80208-2.
10
[Angioma in infants: favorable effect of intravenous hydrocortisone].[婴儿血管瘤：静脉注射氢化可的松的良好效果]
Arch Fr Pediatr. 1971 Apr;28(4):443-4.