Kasim-Karakas Sidika E, Almario Rogelio U, Gregory Laura, Wong Rodney, Todd Heather, Lasley Bill L
Department of Internal Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of California, Davis, California 95616, USA.
J Clin Endocrinol Metab. 2004 Feb;89(2):615-20. doi: 10.1210/jc.2003-030666.
Effects of a polyunsaturated fatty acid (PUFA)-rich diet were investigated in 17 polycystic ovary syndrome (PCOS) patients. After a 3-month habitual diet period, dietary fats were partly replaced with PUFAs for another 3 months. The PUFA-rich diet increased plasma linoleic acid from 28.36 +/- 1.00% to 33.76 +/- 1.08% (P < 0.002) and alpha-linolenic acid from 0.52 +/- 0.03% to 1.06 +/- 0.10% (P < 0.0001). Fasting glucose increased from 76 +/- 3 to 95 +/- 3 mg/dl (4.2 +/- 0.2 to 5.30.2 mmol/liter; P < 0.0001), and the area under the curve for glucose during oral glucose tolerance test increased from 421 +/- 34 to 503 +/- 31 mg/dl (23.4 +/- 1.9 to 27.9 +/- 1.7 mmol/liter; P < 0.001). Plasma insulin did not change either at fasting or during oral glucose tolerance test. Fasting plasma free fatty acids decreased from 0.596 +/- 0.048 to 0.445 +/- 0.058 mg/dl (P = 0.037), and ketone bodies decreased from 9.14 +/- 1.57 to 3.63 +/- 0.62 mg/dl (895 +/- 154 to 356 +/- 61 micromol/liter; P < 0.003). Plasma 15-deoxyprostaglandin J(2) tended to decrease (from 239 +/- 65 to 171 +/- 60 ng/ml; P = 0.053). Plasma testosterone, free testosterone, SHBG, dehydroepiandrosterone sulfate, LH, FSH, and urinary estrogen conjugates did not change. Urinary pregnanediol 3-glucuronide increased from 18.6 +/- 2.2 to 31.0 +/- 5.7 micro g/mg creatinine (P = 0.038). In conclusion, increased dietary PUFA intake can exert significant metabolic and endocrine effects in women with PCOS.
在17名多囊卵巢综合征（PCOS）患者中研究了富含多不饱和脂肪酸（PUFA）饮食的影响。在3个月的习惯饮食期后，膳食脂肪部分被多不饱和脂肪酸替代，持续3个月。富含多不饱和脂肪酸的饮食使血浆亚油酸从28.36±1.00%增加到33.76±1.08%（P<0.002），α-亚麻酸从0.52±0.03%增加到1.06±0.10%（P<0.0001）。空腹血糖从76±3增加到95±3mg/dl（4.2±0.2到5.3±0.2mmol/升；P<0.0001），口服葡萄糖耐量试验期间葡萄糖曲线下面积从421±34增加到503±31mg/dl（23.4±1.9到27.9±1.7mmol/升；P<0.001）。空腹或口服葡萄糖耐量试验期间血浆胰岛素均未改变。空腹血浆游离脂肪酸从0.596±0.048降低到0.445±0.058mg/dl（P=0.037），酮体从9.14±1.57降低到3.63±0.62mg/dl（895±154到356±61μmol/升；P<0.003）。血浆15-脱氧前列腺素J(2)有降低趋势（从239±65到171±60ng/ml；P=0.053）。血浆睾酮、游离睾酮、性激素结合球蛋白、硫酸脱氢表雄酮、促黄体生成素、促卵泡生成素以及尿雌激素结合物均未改变。尿孕二醇3-葡萄糖醛酸苷从18.6±2.2增加到31.0±5.7μg/mg肌酐（P=0.038）。总之，增加膳食多不饱和脂肪酸摄入量可对PCOS女性产生显著的代谢和内分泌影响。
