Panoussopoulos Dimitris, Theodoropoulos George, Lazaris Andreas C, Papadimitriou Konstantina
First Propaedeutic Surgical Department of Hippocration University Hospital, Athens, Greece.
Int J Surg Pathol. 2004 Jan;12(1):79-85. doi: 10.1177/106689690401200115.
A rare case of primary pleomorphic liposarcoma of the thigh with a myxoid component, in which divergent differentiation to a well-differentiated chondrosarcoma was focally present, is described. Presence of heterologous elements has mainly been recognized in the context of dedifferentiated liposarcomas. Few cases of benign mesenchymal tissue have also been reported in well-differentiated and myxoid liposarcomas, while divergent sarcomatous differentiation in liposarcomas appears to be also rare in the absence of dedifferentiation. Positive immunostaining of transforming growth factor-beta, which seems to play a role in the formation of bone and cartilage, was demonstrated in our case. Review of the existing literature on the subject has been carried out.
本文描述了一例罕见的大腿原发性多形性脂肪肉瘤，伴有黏液样成分，其中局部出现向高分化软骨肉瘤的异向分化。异源性成分主要在去分化脂肪肉瘤中被认识到。在高分化和黏液样脂肪肉瘤中也有少数良性间充质组织的病例报道，而在没有去分化的情况下，脂肪肉瘤中的异向肉瘤样分化似乎也很罕见。在我们的病例中，转化生长因子-β免疫染色呈阳性，该因子似乎在骨和软骨形成中起作用。我们对该主题的现有文献进行了综述。
