Tandon N, Marwaha R K, Kalra S, Gupta Nandita, Dudha A, Kochupillai N
Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Natl Med J India. 2003 Nov-Dec;16(6):298-302.
Several recent studies indicate a marked prevalence of vitamin D deficiency in asymptomatic, apparently healthy urban subjects from different socioeconomic groups in north India.
To further examine this trend, we studied 40 men and 50 women, 20-30 years of age, from the Indian paramilitary forces. These individuals consume a nutritious, high-protein diet, have optimal exposure to sunlight and undertake strenuous outdoor physical exercise.
The mean serum calcium, phosphorus and alkaline phosphatase levels were normal in both men and women. The mean (SD) serum intact parathyroid hormone and 25-hydroxyvitamin D3 levels were 19.3 (8.2) pg/ml and 18.4 (5.3) ng/ml in men, and 11.9 (6.6) pg/ml and 25.3 (7.4) ng/ml in women. Bone mineral density estimated in 20 men and 22 women revealed that in comparison with white Caucasians, 35%-50% of men and 14%-32% of women were osteopenic at different sites, while an additional 10% of men had osteoporosis of the lumbar spine.
We found that with optimal nutrition, good sunlight exposure and regular physical exercise, healthy young individuals have normal bone and mineral biochemical values. The reasons for the abnormalities detected in bone mineral density in them needs further study. The impact of childhood nutrition on accumulation of peak bone mass may contribute to our findings. There is a need for establishing normative bone mineral density data for Indians.
最近的几项研究表明，印度北部不同社会经济群体中无症状、看似健康的城市人群维生素D缺乏现象普遍。
为进一步研究这一趋势，我们对40名男性和50名年龄在20至30岁的女性进行了研究，这些人来自印度准军事部队。这些人食用营养丰富的高蛋白饮食，有充足的阳光照射，并进行剧烈的户外体育锻炼。
男性和女性的血清钙、磷和碱性磷酸酶平均水平均正常。男性血清完整甲状旁腺激素和25-羟基维生素D3平均（标准差）水平分别为19.3（8.2）pg/ml和18.4（5.3）ng/ml，女性分别为11.9（6.6）pg/ml和25.3（7.4）ng/ml。对20名男性和22名女性进行的骨密度评估显示，与白种人相比，35%-50%的男性和14%-32%的女性在不同部位存在骨质减少，另有10%的男性腰椎患有骨质疏松症。
我们发现，在营养优化、阳光照射良好和定期体育锻炼的情况下，健康的年轻人骨骼和矿物质生化指标正常。他们骨密度检测异常的原因需要进一步研究。儿童期营养对峰值骨量积累的影响可能是我们研究结果的原因之一。有必要建立印度人的骨密度标准数据。
