Sanghera Dharambir K, Sapkota Bishwa R, Aston Christopher E, Blackett Piers R
Department of Pediatrics, Section of Genetics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Ann Nutr Metab. 2017;70(2):79-87. doi: 10.1159/000458765. Epub 2017 Mar 18.
Vitamin D deficiency is an unrecognized epidemic found in India and also worldwide. Despite the high prevalence of diabetes among Indians, there is a paucity of data showing the relationship between vitamin D status and cardiometabolic disparities. In this study, we have examined the relationship between vitamin D and cardiometabolic traits in a population from India.
Circulating 25(OH)D levels were measured in 3,879 participants from the Asian Indian Diabetic Heart Study using ELISA kits.
Vitamin D levels were significantly reduced (p < 0.0001) in both men and women with obesity. However, compared to women, serum vitamin D was consistently lower in men (p < 0.02), irrespective of the presence of obesity and type 2 diabetes. Multivariate regression revealed strong interaction of vitamin D with body mass index that resulted in increased fasting glucose (p = 0.001) and reduced homeostasis model assessment of β-cell function (HOMA-B; p = 0.01) in normoglycemic individuals. However, in gender-stratified analysis, this association was restricted to men for both fasting glucose (p = 2.4 × 10-4) and HOMA-B (p = 0.001).
Our findings suggest that vitamin D deficiency may significantly enhance the risk of cardiometabolic disease among Asian Indians. Future randomized trials and genetic studies are expected to clarify the underlying mechanisms for gender differences in vitamin D deficiency, and whether vitamin D-driven improvement in testosterone may contribute to beneficial cardiometabolic outcomes in men.
维生素D缺乏是在印度乃至全球都未被认识到的一种流行病。尽管印度人群中糖尿病患病率很高，但缺乏数据表明维生素D状态与心脏代谢差异之间的关系。在本研究中，我们调查了印度人群中维生素D与心脏代谢特征之间的关系。
使用酶联免疫吸附测定试剂盒，对来自亚洲印度糖尿病心脏研究的3879名参与者测定循环25(OH)D水平。
肥胖男性和女性的维生素D水平均显著降低（p < 0.0001）。然而，与女性相比，无论是否存在肥胖和2型糖尿病，男性的血清维生素D水平始终较低（p < 0.02）。多变量回归显示，维生素D与体重指数之间存在强烈的相互作用，这导致血糖正常个体的空腹血糖升高（p = 0.001），β细胞功能的稳态模型评估降低（HOMA-B；p = 0.01）。然而，在按性别分层的分析中，这种关联在空腹血糖（p = 2.4×10-4）和HOMA-B（p = 0.001）方面均仅限于男性。
我们的研究结果表明，维生素D缺乏可能会显著增加亚洲印度人患心脏代谢疾病的风险。未来的随机试验和基因研究有望阐明维生素D缺乏性别差异的潜在机制，以及维生素D驱动的睾酮改善是否可能有助于男性获得有益的心脏代谢结果。
