Hammer C J, Quigley J D, Ribeiro L, Tyler H D
APC, Inc., Ames, IA 50010, USA.
J Dairy Sci. 2004 Jan;87(1):106-11. doi: 10.3168/jds.S0022-0302(04)73147-1.
The objective of this study was to characterize absorption of colostrum replacer (CR) or supplement (CS) containing fractions of bovine plasma. Immunoglobulin concentrate (IGC) was prepared from bovine blood to a final purity of approximately 90% IgG. Blood was also processed to produce a fraction containing elevated concentrations of IGF-I and TGF-beta (GF). Both IGC and GF were spray-dried and blended with other ingredients to produce CR (30% IgG) or CS (15% IgG) containing 0 or 5% GF. Holstein bull calves were assigned to one of five treatments: 1) Pooled colostrum (MC)--1.9 L of pooled colostrum at 1 and 8 h of age to provide over 150 g of IgG; 2) Low supplement (LC)--1.9 L of CS at 1 and 8 h of age to provide 150 g of IgG; 3) Low supplement + GF (LG)--1.9 L of a CS with GF at 1 and 8 h of age to provide 150 g of IgG; 4) High supplement (HC)--1.9 L of CR at 1 h of age to provide 150 g of IgG and 1.9 L of a commercial milk replacer (MR) at 8 h of age; and 5) High supplement + GF (HG)--1.9 L of a CR with GF at 1 h of age to provide 150 g of IgG and 1.9 L of MR at 8 h of age. Apparent efficiency of IgG absorption was higher for calves fed HC and HG compared with those fed LC and LG and was lower for calves fed LG and HG compared with those fed LC and HC. IgG concentrations at 24 h were highest in calves fed MC compared with other calves and were higher in calves fed HC and HG compared to LC and LG. Calves fed LG and HG had lower IgG concentrations at 24 h of age compared with those fed LC and HC. These results indicate that 150 g of IgG provided in one dose soon after birth is superior to 150 g of IgG fed in two doses 7 h apart. Also, addition of a plasma fraction containing elevated concentrations of IGF-I and TGF-beta decreased IgG absorption in the neonatal calf.
本研究的目的是对含有牛血浆成分的初乳代用品（CR）或补充剂（CS）的吸收情况进行表征。从牛血液中制备免疫球蛋白浓缩物（IGC），最终纯度约为90%的IgG。血液还经过处理以产生含有升高浓度的IGF-I和TGF-β（GF）的组分。IGC和GF均进行喷雾干燥，并与其他成分混合以生产含有0%或5% GF的CR（30% IgG）或CS（15% IgG）。荷斯坦公牛犊被分配到五种处理之一：1）混合初乳（MC）——在1小时和8小时龄时各喂1.9升混合初乳，以提供超过150克的IgG；2）低补充剂组（LC）——在1小时和8小时龄时各喂1.9升CS，以提供150克的IgG；3）低补充剂 + GF组（LG）——在1小时和8小时龄时各喂1.9升含GF的CS，以提供150克的IgG；4）高补充剂组（HC）——在1小时龄时喂1.9升CR以提供150克的IgG，并在8小时龄时喂1.9升商业代乳粉（MR）；5）高补充剂 + GF组（HG）——在1小时龄时喂1.9升含GF的CR以提供150克的IgG，并在8小时龄时喂1.9升MR。与喂LC和LG的犊牛相比，喂HC和HG的犊牛IgG的表观吸收效率更高；与喂LC和HC的犊牛相比，喂LG和HG的犊牛IgG的表观吸收效率更低。与其他犊牛相比，喂MC的犊牛在24小时时的IgG浓度最高；与LC和LG相比，喂HC和HG的犊牛在24小时时的IgG浓度更高。与喂LC和HC的犊牛相比，喂LG和HG的犊牛在24小时龄时的IgG浓度更低。这些结果表明，出生后不久一次剂量提供150克的IgG优于间隔7小时分两次喂150克的IgG。此外，添加含有升高浓度的IGF-I和TGF-β的血浆组分可降低新生犊牛的IgG吸收。
