Rocha G, Baines M G, Deschênes J
Department of Microbiology and Immunology, McGill University, Montreal, Canada.
Crit Rev Immunol. 1992;12(3-4):81-100.
Advances in immunology have provided us with new insights about the ocular inflammatory response. Still, the etiology and pathophysiology of many uveitides remain unclear. Factors such as the blood-ocular barrier, sequestration of retinal antigens, local immunomodulators in the aqueous humor, and anterior chamber-associated immune deviation (ACAID) interact and render the eye an immunologically "privileged" site. On the other hand, human leukocyte antigen complex (HLA) interactions, the immunopathology of hypersensitivity reactions, T-cell mediated disease, and autoimmunity are associated pathogenic mechanisms of immune-related ocular disease. In this paper, we review some of the immunologic characteristics of the eye and their relationship to intraocular inflammation. Clinocopathologic correlations are presented. Also, perspectives of current and future research, as well as diagnostic and treatment strategies, are discussed.
免疫学的进展为我们提供了关于眼部炎症反应的新见解。尽管如此，许多葡萄膜炎的病因和病理生理学仍不清楚。血眼屏障、视网膜抗原隔离、房水中的局部免疫调节剂以及前房相关免疫偏离（ACAID）等因素相互作用，使眼睛成为一个免疫“特权”部位。另一方面，人类白细胞抗原复合体（HLA）相互作用、超敏反应的免疫病理学、T细胞介导的疾病和自身免疫是免疫相关眼病的相关致病机制。在本文中，我们回顾了眼睛的一些免疫学特征及其与眼内炎症的关系。展示了临床病理相关性。此外，还讨论了当前和未来研究的前景以及诊断和治疗策略。
