Kubicka A
Katedry i Kliniki Okulistyki CM UJ w Krakowie.
Klin Oczna. 1995 Mar-Apr;97(3-4):90-2.
It has long been known that eye is an immunologically privileged organ. This is concerned with central and peripheral mechanisms that control the eye immunological tolerance. New models of human inflammatory eye disorders were induced in laboratory animals by immunization with photoreceptor antigens (EAU) and retinal pigmented epithelium antigens (EAAU and EAPU). Continual investigations on eye immunological response mechanisms indicated the central role of lymphocyte T-helper, although reactions with circulating immune complexes cannot be excluded. Individual susceptibility to autoimmune uveitic disorders is genetically controlled and is regulated by MHC-antigens and by non-MHC dependent factors, and the latter ones seem to play a more important role.
长期以来，人们都知道眼睛是一个免疫赦免器官。这与控制眼部免疫耐受的中枢和外周机制有关。通过用感光受体抗原（实验性自身免疫性葡萄膜炎）和视网膜色素上皮抗原（实验性自身免疫性全葡萄膜炎和实验性自身免疫性色素上皮炎）免疫实验室动物，诱导出了人类炎性眼病的新模型。对眼部免疫反应机制的持续研究表明，淋巴细胞辅助性T细胞起核心作用，不过与循环免疫复合物的反应也不能排除。个体对自身免疫性葡萄膜疾病的易感性受基因控制，由主要组织相容性复合体抗原和非主要组织相容性复合体依赖性因素调节，而后者似乎发挥着更重要的作用。
