Rogers Arlin B, Fox James G
Comparative Pathology Laboratory, Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave., Bldg. 16-849, Cambridge, MA 02139, USA.
Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G361-6. doi: 10.1152/ajpgi.00499.2003.
Chronic gastrointestinal and liver infections account for a significant percentage of human cancer deaths. Rodent models help elucidate how infection can lead to malignancy. Helicobacter pylori, the leading cause of human gastric tumors, produces similar disease in Mongolian gerbils. H. pylori, H. felis, and H. hepaticus induce stomach, lower bowel, or liver tumors in susceptible wild-type and genetically engineered mice. Immune dysregulated mice recapitulate features of inflammatory bowel disease including colon carcinoma. Hepatitis B and C virus transgenic mice provide insights into viral hepatitis and hepatocellular carcinoma. Rodent models enhance our understanding of infectious cancer pathogenesis and suggest novel targets for intervention.
慢性胃肠道和肝脏感染在人类癌症死亡中占相当大的比例。啮齿动物模型有助于阐明感染如何导致恶性肿瘤。幽门螺杆菌是人类胃肿瘤的主要病因，可在蒙古沙鼠中引发类似疾病。幽门螺杆菌、猫幽门螺杆菌和肝螺杆菌可在易感的野生型和基因工程小鼠中诱发胃部、下肠道或肝脏肿瘤。免疫失调的小鼠重现了包括结肠癌在内的炎症性肠病的特征。乙型和丙型肝炎病毒转基因小鼠为病毒性肝炎和肝细胞癌提供了见解。啮齿动物模型增进了我们对感染性癌症发病机制的理解，并为干预提供了新的靶点。
