Chen Duan, Stenström Björn, Zhao Chun-Mei, Wadström Torkel
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
FEMS Immunol Med Microbiol. 2007 Jul;50(2):184-9. doi: 10.1111/j.1574-695X.2007.00249.x.
A role for Helicobacter pylori infection in the development of gastric cancer in humans is well established; however, evidence for its carcinogenicity in animals remains inadequate. Mongolian gerbils and mice are commonly used to investigate the carcinogenicity of H. pylori, yet it is unclear whether H. pylori infection per se causes gastric cancer or duodenal ulcers in these animal models. Gastric adenocarcinoma in the gerbils was reported over 10 years ago, but this species has proved an unreliable model for studying H. pylori infection-associated gastric cancer. Helicobacter pylori infection alone appears insufficient to induce gastric cancer in these animals; additional carcinogenic insult is required. The development of invasive adenocarcinoma in inbred mice is rare regardless of the mouse or bacterial strain, and many long-term studies have failed to induce gastric cancer in these animals. Helicobacter pylori infection is also an established causative factor for duodenal ulcer in humans. However, few studies have attempted to develop animal models of H. pylori infection-induced duodenal ulcer. We therefore conclude that both Mongolian gerbils and inbred mice may be inadequate models for studying H. pylori infection-associated gastric cancer and that there is no animal model of H. pylori infection-induced duodenal ulcer.
幽门螺杆菌感染在人类胃癌发生过程中的作用已得到充分证实；然而，其在动物体内致癌性的证据仍然不足。蒙古沙鼠和小鼠常用于研究幽门螺杆菌的致癌性，但在这些动物模型中，幽门螺杆菌感染本身是否会导致胃癌或十二指肠溃疡尚不清楚。10多年前就有关于沙鼠胃腺癌的报道，但事实证明该物种在研究幽门螺杆菌感染相关胃癌方面是不可靠的模型。仅幽门螺杆菌感染似乎不足以在这些动物中诱发胃癌；还需要额外的致癌刺激。无论小鼠或细菌菌株如何，近交系小鼠侵袭性腺癌的发生都很罕见，许多长期研究都未能在这些动物中诱发胃癌。幽门螺杆菌感染也是人类十二指肠溃疡的既定致病因素。然而，很少有研究尝试建立幽门螺杆菌感染诱导的十二指肠溃疡动物模型。因此，我们得出结论，蒙古沙鼠和近交系小鼠可能都不是研究幽门螺杆菌感染相关胃癌的理想模型，而且不存在幽门螺杆菌感染诱导的十二指肠溃疡动物模型。
