Morss Gina M, Jordan Alex N, Skinner James S, Dunn Andrea L, Church Timothy S, Earnest Conrad P, Kampert James B, Jurca Radim, Blair Steven N
Centers for Integrated Health Research, The Cooper Institute, 12330 Preston Road, Dallas, TX 75230, USA.
Med Sci Sports Exerc. 2004 Feb;36(2):336-44. doi: 10.1249/01.MSS.0000113738.06267.E5.
Physical inactivity in postmenopausal women contributes to a rise in atherogenic risk factors associated with the metabolic syndrome. Although regular physical activity positively contributes to health, inactivity progressively increases with age. The Dose Response to Exercise in Women aged 45-75 yr (DREW) study is designed to investigate the effect of different amounts of exercise training on cardiorespiratory fitness and risk factors for cardiovascular disease (CVD) in postmenopausal women at moderately increased risk of CVD.
DREW will recruit 450 sedentary, healthy, postmenopausal women with a body mass index of 25-40 kg.m-2, resting systolic blood pressure (BP) of 120-159 mm Hg, and a resting diastolic BP of < or = 99 mm Hg. Laboratory and self-report measures completed at baseline and 6 months include maximal oxygen consumption (.VO2max), resting BP, anthropometry, dietary habits, physical activity history, medication use, menstrual history, personal and family medical history, and fasting HDL cholesterol, LDL cholesterol, triglycerides, and glucose. Eligible participants are randomly assigned to a nonexercise group or one of three exercise groups. Participants exercise 3 to 4x wk-1 at a heart rate equivalent to 50% of .VO2max expending 4, 8, or 12 kcal.kg-1.wk-1, depending on group assignment. This study will allow quantification of possible dose-response relations (50%, 100%, and 150% of the consensus physical activity recommendation) between exercise training and study outcomes.
DREW can make important contributions to our understanding of the effects of physical activity in postmenopausal women and help refine public health and clinical recommendations for this group.
绝经后女性缺乏体育活动会导致与代谢综合征相关的致动脉粥样硬化危险因素增加。尽管规律的体育活动对健康有积极作用，但缺乏运动的情况会随着年龄增长而逐渐增加。45 - 75岁女性运动剂量反应（DREW）研究旨在调查不同运动量的运动训练对心血管疾病（CVD）中度风险增加的绝经后女性的心肺适能和心血管疾病危险因素的影响。
DREW将招募450名久坐不动、健康的绝经后女性，她们的体重指数为25 - 40 kg·m⁻²，静息收缩压（BP）为120 - 159 mmHg，静息舒张压≤99 mmHg。在基线和6个月时完成的实验室和自我报告测量包括最大摄氧量（.VO₂max）、静息血压、人体测量、饮食习惯、体育活动史、药物使用、月经史、个人和家族病史，以及空腹高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯和血糖。符合条件的参与者被随机分配到非运动组或三个运动组之一。参与者每周进行3至4次运动，心率相当于.VO₂max的50%，根据分组分配，每周消耗4、8或12 kcal·kg⁻¹·wk⁻¹。这项研究将能够量化运动训练与研究结果之间可能的剂量反应关系（共识体育活动建议量的50%、100%和150%）。
DREW可以为我们理解体育活动对绝经后女性的影响做出重要贡献，并有助于完善针对该群体的公共卫生和临床建议。
