Bush Robert K, Prochnau Jay J
Department of Medicine, University of Wisconsin Medical, Madison, Wis, USA.
J Allergy Clin Immunol. 2004 Feb;113(2):227-34. doi: 10.1016/j.jaci.2003.11.023.
Acute, severe asthma attacks can be precipitated by a variety of stimuli including exposure to aeroallergens, viral respiratory infections, pollutants, and occupational chemicals. Alternaria is a major aeroallergen in many parts of the world. Sensitivity to Alternaria has been increasingly recognized as a risk factor for the development and persistence of asthma, asthma severity, and potentially fatal asthma exacerbations. We present the case of a patient with IgE-mediated sensitivity to Alternaria who developed an acute, life-threatening asthma attack during the peak Alternaria season. We describe the aerobiology, pathophysiobiology, diagnosis, and treatment options for patients with Alternaria-induced asthma.
急性重症哮喘发作可由多种刺激因素诱发，包括接触气传变应原、病毒性呼吸道感染、污染物和职业性化学物质。链格孢属真菌是世界许多地区的主要气传变应原。对链格孢属真菌敏感已日益被认为是哮喘发生、持续、严重程度以及潜在致命性哮喘加重的一个危险因素。我们报告一例对链格孢属真菌具有IgE介导敏感性的患者，该患者在链格孢属真菌高峰季节发生了急性、危及生命的哮喘发作。我们描述了链格孢属真菌诱发哮喘患者的空气生物学、病理生理生物学、诊断及治疗选择。
