Sou Reika, Oku Naohiko, Ohguro Nobuyuki, Hibino Sawako, Fujikado Takashi, Tano Yasuo
Department of Ophthalmology, Osaka University Medical School, Osaka, Japan.
Jpn J Ophthalmol. 2004 Jan-Feb;48(1):54-8. doi: 10.1007/s10384-003-0016-0.
Single photon emission computed tomography (SPECT) images with N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) have recently been used for the sensitive and specific detection of melanoma.
Using 123I-IMP SPECT, we observed three patients over a period of 18 months in whom choroidal melanoma had been diagnosed. Two underwent radiotherapy (cyber knife) in our clinic; the other patient was referred to us after 8 months of proton beam irradiation at another clinic.
In two of the three cases, no metastasis or tumor recurrence has been observed up to the present time. In these individuals, the average 123I-IMP uptake in the pathological eye gradually and progressively decreased after radiotherapy to levels seen in the fellow eye. One eye of the three patients examined here, however, exhibited tumor recurrence in the ciliary body as well as hepatic metastasis 12 months after radiation treatment. In the pathological eye of this patient, the average 123I-IMP uptake gradually decreased, but never reached the levels in the fellow eye during the observation period.
123I-IMP SPECT is a useful examination method not only for diagnosis but also for the follow-up of patients with choroidal melanoma.
使用 N-异丙基-p-[123I]-碘安非他明（123I-IMP）的单光子发射计算机断层扫描（SPECT）图像最近已用于黑色素瘤的灵敏且特异的检测。
使用 123I-IMP SPECT，我们在 18 个月期间观察了 3 例已诊断为脉络膜黑色素瘤的患者。其中 2 例在我们诊所接受了放射治疗（射波刀）；另 1 例患者在另一家诊所接受质子束照射 8 个月后转诊至我们这里。
在这 3 例中的 2 例中，截至目前未观察到转移或肿瘤复发。在这些个体中，放疗后患眼的平均 123I-IMP 摄取逐渐且持续下降至对侧眼所见水平。然而，在此检查的 3 例患者中的 1 例，在放射治疗 12 个月后，睫状体出现肿瘤复发并伴有肝转移。在该患者的患眼中，平均 123I-IMP 摄取逐渐下降，但在观察期内从未达到对侧眼的水平。
123I-IMP SPECT 不仅是一种用于诊断脉络膜黑色素瘤患者的有用检查方法，也是用于随访的有用检查方法。
