Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba City, Chiba, 263-8555, Japan.
Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Ann Nucl Med. 2020 Nov;34(11):864-872. doi: 10.1007/s12149-020-01517-z. Epub 2020 Sep 9.
The aim of this study was to assess the diagnostic ability of N-isopropyl-p-[I-123] iodoamphetamine (IMP) SPECT semi-quantitative evaluation based on the standardized uptake value (SUV) in patients with choroidal melanoma. The secondary aim was to investigate the 6-h IMP SPECT imaging in comparison with 24-h imaging.
Twenty-five patients (14 males and 11 females, mean age of 59.2-year-old) were analyzed in this retrospective study. Patients underwent 24-h IMP SPECT imaging with a gamma camera after intravenous injection of IMP. Twelve of 25 patients underwent 6-h SPECT imaging in addition to the 24-h imaging. All acquired SPECT images were fused with CT images using an image-analysis software. To assess the utility of semi-quantitative evaluation method, we introduced an image evaluation method using SUVmax comparing with conventional count-based uptake index (UI) evaluation of the lesion. Volumes-of-interest (VOIs) for SUVmax and regions-of-interest (ROIs) for UI were drawn referring to the SPECT-CT fusion image. Then the relationship between the 6- and 24-h images was examined both in SUV and UI evaluation. Furthermore, the relationship between the size category classification (SCC) by UICC/AJCC: 1-4 scales and each semi-quantitative value using SUVmax and UI was also assessed.
SUVmax of the tumor was significantly higher than that of the normal side; 2.37 ± 0.88 and 1.77 ± 0.39 (P < 0.05) on 6-h image, 4.17 ± 1.73 and 2.04 ± 0.45 (P < 0.001) on 24-h image, respectively. UI of the tumor was also significantly higher than that of the normal side; 2.24 ± 0.67 and 1.53 ± 0.35 (P < 0.01) on 6-h image, 3.79 ± 1.24 and 1.67 ± 0.44 (P < 0.001) on 24-h image, respectively. There was a strong significant linear relationship in the evaluation with SUVmax between 6- and 24-h on the tumor side (R = 0.88, P < 0.0001), compared to that with Tumor-UI (R = 0.35, P < 0.05). In addition, SUVmax of the tumor clearly differentiated the SCC of the tumor category 4 from that of category 1, where SUVmax of the tumor for categories 1‒4 were 2.56 ± 0.59, 4.33 ± 1.92, 4.63 ± 1.45, and 5.73 ± 1.69, respectively (P < 0.05, for categories 1 and 4).
The semi-quantitative evaluation by SUV of I-IMP SPECT images fused with CT images is useful for detecting choroidal melanoma. Moreover, 6-h imaging with SUV-based evaluation of I-IMP SPECT is promising compared to the conventional count-based UI evaluation method. Trial registration This study is registered in UMIN Clinical Trials Registry (UMIN-CTR) as UMIN study ID: UMIN000038174.
本研究旨在评估基于标准化摄取值（SUV）的 N-异丙基-p-[I-123]碘苯丙胺（IMP）SPECT 半定量评估在脉络膜黑色素瘤患者中的诊断能力。次要目的是研究 6 小时 IMP SPECT 成像与 24 小时成像的比较。
回顾性分析 25 例患者（男 14 例，女 11 例，平均年龄 59.2 岁）。患者静脉注射 IMP 后，使用伽玛相机进行 24 小时 IMP SPECT 成像。25 例患者中有 12 例除了 24 小时成像外，还进行了 6 小时 SPECT 成像。所有采集的 SPECT 图像均使用图像分析软件与 CT 图像融合。为了评估半定量评估方法的效用，我们引入了一种使用 SUVmax 的图像评估方法，与传统的基于计数的摄取指数（UI）评估病变进行比较。SUVmax 的感兴趣区（VOI）和 UI 的感兴趣区（ROI）是根据 SPECT-CT 融合图像绘制的。然后，在 SUV 和 UI 评估中，检查了 6 小时和 24 小时图像之间的关系。此外，还评估了 UICC/AJCC 1-4 级分类（SCC）与 SUVmax 和 UI 之间的每个半定量值之间的关系。
肿瘤的 SUVmax 明显高于健侧；6 小时时为 2.37±0.88 和 1.77±0.39（P<0.05），24 小时时为 4.17±1.73 和 2.04±0.45（P<0.001）。肿瘤的 UI 也明显高于健侧；6 小时时为 2.24±0.67 和 1.53±0.35（P<0.01），24 小时时为 3.79±1.24 和 1.67±0.44（P<0.001）。与肿瘤 UI 相比，肿瘤侧 6 小时和 24 小时 SUVmax 评估之间存在很强的线性关系（R=0.88，P<0.0001）。此外，肿瘤的 SUVmax 可以清楚地区分肿瘤 SCC 4 类与 1 类，肿瘤 SCC 1-4 类的 SUVmax 分别为 2.56±0.59、4.33±1.92、4.63±1.45 和 5.73±1.69（P<0.05，对于类别 1 和 4）。
与传统的基于计数的 UI 评估方法相比，基于 CT 图像融合的 IMP SPECT 图像的 SUV 半定量评估对于检测脉络膜黑色素瘤是有用的。此外，与传统的基于计数的 UI 评估方法相比，基于 SUV 的 6 小时 IMP SPECT 成像具有更大的应用潜力。
这是一篇关于医学研究的文章，其中涉及了一些专业的医学术语和概念。在翻译过程中，需要确保翻译的准确性和专业性。同时，由于这是一篇研究论文，因此需要使用正式、准确的语言，避免使用口语化或随意的表达方式。
