Abe Koichiro, Sasaki Masayuki, Koga Hirofumi, Kaneko Koichiro, Sawamoto Hirofumi, Yoshikawa Hiroshi, Honda Hiroshi
Department of Clinical Radiology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Nucl Med Commun. 2007 Jul;28(7):567-73. doi: 10.1097/MNM.0b013e328194f221.
To evaluate the efficacy of (123)I-IMP single photon emission computed tomography (SPECT) for the diagnosis of ocular malignant melanoma (MM).
Thirty-eight patients (18 males, 20 females) clinically suspected of having ocular MM were retrospectively examined in this study. The age of patients ranged from 8 to 81 years (mean 55.6 years). Twelve patients were finally diagnosed as having ocular MM. Orbital SPECT images were taken 15 min, 4 h, 24 h and 48 h after intravenous injection of 111-222 MBq (3-6 mCi) (123)I-IMP. (123)I-IMP uptake in the orbital tumor was visually evaluated as-(negative),+/-(equivocal), or+(positive). The uptake index (UI) and increase ratios (IRs) were calculated.
For visual evaluation, the accuracy of (123)I-IMP for the diagnosis of MM was 73.7% (15 min), 81.6% (4 h), 81.6% (24 h) and 86.8% (48 h). When UI and IR were calculated on both the MM and non-MM groups, the UI and IR of the MM group were significantly higher than those of the non-MM group (P<0.001). Moreover, the highest sensitivity (100%) and accuracy (94.7%) were obtained 48 h after (123)I-IMP administration when the cut-off value of UI was defined as 1.90.
This study shows that (123)I-IMP SPECT is useful for the diagnosis of ocular MM. The UI values 48 h after the injection were efficient for the differentiation between MM and non-MM lesions.
评估¹²³I-异碘普胺单光子发射计算机断层扫描（SPECT）诊断眼部恶性黑色素瘤（MM）的效能。
本研究回顾性检查了38例临床怀疑患有眼部MM的患者（18例男性，20例女性）。患者年龄为8至81岁（平均55.6岁）。最终12例患者被诊断为眼部MM。静脉注射111 - 222 MBq（3 - 6 mCi）¹²³I-异碘普胺后15分钟、4小时、24小时和48小时进行眼眶SPECT成像。通过视觉评估眼眶肿瘤中¹²³I-异碘普胺的摄取情况，分为 -（阴性）、±（可疑）或 +（阳性）。计算摄取指数（UI）和增加率（IR）。
视觉评估方面，¹²³I-异碘普胺诊断MM的准确率在15分钟时为73.7%，4小时时为81.6%，24小时时为81.6%，48小时时为86.8%。计算MM组和非MM组的UI和IR后发现，MM组的UI和IR显著高于非MM组（P<0.001）。此外，当将UI的截断值定义为1.90时，¹²³I-异碘普胺给药后48小时获得了最高灵敏度（100%）和准确率（94.7%）。
本研究表明¹²³I-异碘普胺SPECT对眼部MM的诊断有用。注射后48小时的UI值有助于区分MM和非MM病变。
