Kurtz Trisha A, Fineberg Naomi S, Considine Robert V, Deeg Mark A
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Metabolism. 2004 Feb;53(2):138-9. doi: 10.1016/j.metabol.2003.09.004.
The dyslipidemia of the metabolic syndrome is associated with alterations in triglyceride and high-density lipoprotein (HDL) metabolism. We examined the serum levels of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a minor HDL-associated protein, in a cohort with a wide range of insulin sensitivity. The mean serum GPI-PLD mass from 109 subjects was 58.9 +/- 18.4 microg/mL (mean +/- SD). GPI-PLD levels directly correlated with cholesterol, apolipoprotein AI, triglycerides, insulin, and homeostasis model assessment (HOMA) but not C-reactive protein. These results suggest that increased serum GPI-PLD is associated with the insulin resistance.
代谢综合征的血脂异常与甘油三酯及高密度脂蛋白（HDL）代谢改变有关。我们在一个胰岛素敏感性范围广泛的队列中检测了糖基磷脂酰肌醇特异性磷脂酶D（GPI-PLD，一种与HDL相关的次要蛋白）的血清水平。109名受试者的血清GPI-PLD平均质量为58.9±18.4微克/毫升（均值±标准差）。GPI-PLD水平与胆固醇、载脂蛋白AI、甘油三酯、胰岛素及稳态模型评估（HOMA）直接相关，但与C反应蛋白无关。这些结果表明血清GPI-PLD升高与胰岛素抵抗有关。
