Gray Dona L, O'Brien Kevin D, D'Alessio David A, Brehm Bonnie J, Deeg Mark A
Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Metabolism. 2008 Apr;57(4):473-8. doi: 10.1016/j.metabol.2007.11.007.
Although circulating glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a minor high-density lipoprotein-associated protein, is elevated in patients with insulin resistance or high triglycerides, no information is available on the effect of weight loss or changes in insulin sensitivity on circulating GPI-PLD levels. The objective of the study was to determine the effect of weight loss and changes in insulin sensitivity on plasma GPI-PLD levels. Forty-two nondiabetic obese women were included in the study, which involved a 3-month dietary intervention randomizing patients to a low-fat or a low-carbohydrate diet. The study's main outcome measures were plasma GPI-PLD levels and insulin sensitivity as estimated by the homeostasis model assessment. The very low carbohydrate diet group lost more weight after 3 months (-7.6 +/- 3.2 vs -4.2 +/- 3.5 kg, P < .01), although the decrease in insulin resistance was similar between groups. Weight loss with either diet did not alter plasma GPI-PLD levels. However, baseline GPI-PLD levels correlated with the change in insulin sensitivity in response to the low-fat diet, whereas baseline insulin sensitivity correlated with the change in insulin sensitivity in response to the low-carbohydrate diet. Plasma GPI-PLD may serve as a clinical tool to determine the effect of a low-fat diet on insulin sensitivity.
尽管循环糖基磷脂酰肌醇特异性磷脂酶D（GPI-PLD）是一种与高密度脂蛋白相关的次要蛋白，在胰岛素抵抗或高甘油三酯患者中水平升高，但关于体重减轻或胰岛素敏感性变化对循环GPI-PLD水平的影响尚无相关信息。本研究的目的是确定体重减轻和胰岛素敏感性变化对血浆GPI-PLD水平的影响。42名非糖尿病肥胖女性被纳入研究，该研究包括为期3个月的饮食干预，将患者随机分为低脂饮食组或低碳水化合物饮食组。研究的主要结局指标是血浆GPI-PLD水平和通过稳态模型评估估计的胰岛素敏感性。3个月后，极低碳水化合物饮食组体重减轻更多（-7.6±3.2 vs -4.2±3.5 kg，P<.01），尽管两组胰岛素抵抗的降低相似。两种饮食方式导致的体重减轻均未改变血浆GPI-PLD水平。然而，基线GPI-PLD水平与低脂饮食引起的胰岛素敏感性变化相关，而基线胰岛素敏感性与低碳水化合物饮食引起的胰岛素敏感性变化相关。血浆GPI-PLD可作为一种临床工具，用于确定低脂饮食对胰岛素敏感性的影响。
