Klenerman Paul
Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, GB.
Eur J Immunol. 2004 Feb;34(2):313-6. doi: 10.1002/eji.200324844.
In animal models, lymphocytic choriomeningitis virus (LCMV) may be controlled after acute infection or may establish various levels of persistence. Cytotoxic responses mediated by CD8(+) T cells are responsible for both initial control of LCMV and for immunopathology. As discussed in this article, there is emerging evidence that the levels of antigen to which the immune system is exposed over time are important in controlling CD8(+) T cell activation, memory responses and exhaustion, and that these levels are affected by the efficiency of T cell help and the presence of antibody. To enable lasting control of LCMV infection, CD8(+) T cells, CD4(+) T cell help and B cells are all required. These findings have important implications for the prevention and treatment of infection by viruses such as hepatitis B and C viruses, cytomegalovirus and HIV. See accompanying article http://dx.doi.org/10.1002/eji.200324717
在动物模型中，淋巴细胞性脉络丛脑膜炎病毒（LCMV）在急性感染后可能得到控制，也可能建立不同程度的持续性感染。由CD8(+) T细胞介导的细胞毒性反应既负责LCMV的初始控制，也参与免疫病理学过程。如本文所讨论的，越来越多的证据表明，免疫系统随时间接触的抗原水平对于控制CD8(+) T细胞活化、记忆反应和耗竭很重要，而且这些水平受T细胞辅助效率和抗体存在情况的影响。为实现对LCMV感染的持久控制，CD8(+) T细胞、CD4(+) T细胞辅助和B细胞都是必需的。这些发现对预防和治疗乙型和丙型肝炎病毒、巨细胞病毒及HIV等病毒感染具有重要意义。见配套文章http://dx.doi.org/10.1002/eji.200324717
