Cao Qunhua, Qu Weijing, Deng Yunxia, Zhang Zhicai, Niu Wei, Pan Yifeng
School of Life Science, Normal University of East China, Shanghai 200062.
Zhong Yao Cai. 2003 Oct;26(10):735-7.
To investigate the effect of flavonoids from the seed residue and fruit residue of Hippophae rhamnoides L. (FSH and FFH) on glycometabolism in mice.
The healthy male mice were randomly divided into control group, three FSH treatment groups and three FFH treatment groups. FSH(50, 100, 150 mg/kg) and FFH (50, 100, 150 mg/kg) were given intragastorically(i.g.). At the same time, the mice of control group were given physiological saline. The levels of serum glucose, serum cholesterol were determined when it lasted 7 and 14 days. After 16 days glyconeogenesis test was made and liver glycogen was analyzed.
The levels of serum glucose, serum cholesterol and serum triglyceride were significantly reduced by high dose FSH and FFH. The glyconegenesis was also obviously inhibited by FSH and FFH.
FSH and FFH can decrease the levels of blood glucose and lipid in normal mice, and the effect of FSH and FFH on glycometabolism may be related to the control of glyconeogenesis.
研究沙棘籽渣黄酮（FSH）和沙棘果渣黄酮（FFH）对小鼠糖代谢的影响。
将健康雄性小鼠随机分为对照组、3个FSH治疗组和3个FFH治疗组。分别给予FSH（50、100、150mg/kg）和FFH（50、100、150mg/kg）灌胃，同时对照组小鼠给予生理盐水。持续7天和14天时测定血清葡萄糖、血清胆固醇水平。16天后进行糖异生试验并分析肝糖原。
高剂量FSH和FFH可显著降低血清葡萄糖、血清胆固醇和血清甘油三酯水平。FSH和FFH也明显抑制糖异生。
FSH和FFH可降低正常小鼠的血糖和血脂水平，FSH和FFH对糖代谢的影响可能与控制糖异生有关。
