Kozlovskiĭ A G, Zhelifonova V P, Adanin V M, Antipova T V, Ozerskaia S M, Kochkina G A, Grafe U
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr. Nauki 5, Pushchino, Moscow Oblast, 142290 Russia.
Mikrobiologiia. 2003 Nov-Dec;72(6):816-21.
The study of the secondary metabolites of the relict strain Penicillium citrinum VKM FW-800 isolated from ancient Arctic permafrost sediments showed that this fungus produces agroclavine-1 and epoxyagroclavine-1, which are rare ergot alkaloids with the 5R,10S configuration of the tetracyclic ergoline ring system. The production of the alkaloids by the fungus showed a biphasic behavior, being intense in the phase of active growth and slowing down in the adaptive lag phase and in the stationary growth phase. The addition of zinc ions to the incubation medium led to a fivefold increase in the yield of the alkaloids. The alkaloids-producing Penicillium fungi isolated from different regions exhibited the same tendencies of growth and alkaloid production.
对从古代北极永久冻土沉积物中分离出的残遗菌株桔青霉VKM FW - 800的次生代谢产物的研究表明，这种真菌产生农麦角碱 - 1和环氧农麦角碱 - 1，它们是具有四环麦角灵环系统5R,10S构型的稀有麦角生物碱。该真菌产生生物碱的行为呈双相性，在活跃生长阶段强烈，在适应性延迟阶段和稳定生长阶段减缓。向培养介质中添加锌离子导致生物碱产量增加五倍。从不同地区分离出的产生生物碱的青霉真菌表现出相同的生长和生物碱产生趋势。
