Yosefy Chaim, Ronnen Meir, Edelstein Dennis
Clalit Healthcare, Ganey Barnea, Ashkelon, Israel.
Clin Dev Immunol. 2003 Jun-Dec;10(2-4):193-5. doi: 10.1080/10446670310001642131.
Alopecia Areata (AA) is a disease characterized by hair loss that is widely believed to be autoimmune in origin. Thus treatment is generally aimed in this direction using immune inhibitors such as steroids and PUVA.
To describe a variant of AA, Pseudo Alopecia Areata, caused by a particular cupola pin holder (tic-tac) and to offer a non-pharmacological treatment option (NPT).
A prospective open label study in 37 Jewish religious patients (34 males, 3 females, mean 35 +/- 2 years), previously diagnosed and treated for scalp AA were randomly referred to one of the three NPT intervention methods: small cupola held by two pins, large cupola held by one pin and similar cupola held by a different pin.
Three of the ten patients (33.3%) from the first group developed secondary AA from the additional pin. No changes were seen in the second group. Ten of the seventeen patients (58.8%) from the third group achieved immediate improvement subsequent to replacing the original pin with a new one on a larger cupola.
Conservative pharmacological treatment failed to repair the lesions. The addition of a second pin caused an additional lesion. In contrast, replacing the cupola with a larger one and the original pin-fastener with a different type, successfully reduced the lesions.
斑秃（AA）是一种以脱发为特征的疾病，普遍认为其病因是自身免疫性的。因此，治疗通常朝着这个方向进行，使用类固醇和补骨脂素等免疫抑制剂。
描述一种由特定圆顶别针固定器（tic-tac）引起的斑秃变体——假性斑秃，并提供一种非药物治疗方案（NPT）。
对37名犹太宗教患者（34名男性，3名女性，平均年龄35±2岁）进行前瞻性开放标签研究，这些患者之前已被诊断患有头皮斑秃并接受过治疗，他们被随机分配到三种NPT干预方法中的一种：两根针固定的小杯形物、一根针固定的大杯形物以及用不同别针固定的类似杯形物。
第一组的10名患者中有3名（33.3%）因额外的别针引发了继发性斑秃。第二组未见变化。第三组的17名患者中有10名（58.8%）在将原别针换成更大杯形物上的新别针后立即有所改善。
保守的药物治疗未能修复病变。增加第二根别针导致了额外的病变。相比之下，用更大的杯形物替换以及用不同类型的原别针固定器替换，成功减少了病变。
