Zhang Yu-qiu, Lü Shao-gang, Ji Ya-ping, Zhao Zhi-qi, Mei Jun
Institute of Neurobiology, Fudan University, Shanghai 200433, China.
Acta Pharmacol Sin. 2004 Feb;25(2):161-70.
To investigate the primary electrophysiological and pharmacological properties of the nucleus basalis magnocellularis (nbM) neurons.
Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthetized rats.
Most nbM neurons responded to noxious but not innocuous mechanical, thermal, chemical, and electrical stimuli. The receptive fields were usually very large and bilateral. Electrical stimulation applied to the frontal cortex (FCX) either activated orthodromically or antidromically the nbM neurons. The FCX stimulation-induced excitatory response in the nbM neurons could be partly blocked by intracerebroventricular (icv) injection of atropine 2.5 mmol/L or tubocurarine 0.1 mmol/L. Icv injection of ach (1, 10, and 100 mmol/L) dose-dependently increased the spontaneous firing rate in most of the nbM neurons. Atropine (2.5, 25, and 250 mmol/L) or tubocurarine (0.1, 1, and 10 mmol/L) not only antagonized the ACh-induced excitation, but also inhibited the spontaneous firing of the nbM neurons.
The nbM might be involved in nociception, although it was considered to play a critical role in cognitive function. Also, the nbM appears to be rich in cholinergic autoreceptors.
研究大细胞基底核（nbM）神经元的主要电生理和药理学特性。
在乌拉坦麻醉的大鼠中，用玻璃微电极从nbM神经元进行单单位细胞外记录。
大多数nbM神经元对伤害性刺激有反应，但对无害的机械、热、化学和电刺激无反应。感受野通常非常大且双侧分布。对额叶皮质（FCX）施加电刺激可顺向或逆向激活nbM神经元。FCX刺激诱导的nbM神经元兴奋性反应可被脑室内（icv）注射2.5 mmol/L阿托品或0.1 mmol/L筒箭毒碱部分阻断。icv注射乙酰胆碱（1、10和100 mmol/L）剂量依赖性地增加大多数nbM神经元的自发放电率。阿托品（2.5、25和250 mmol/L）或筒箭毒碱（0.1、1和10 mmol/L）不仅拮抗乙酰胆碱诱导的兴奋，还抑制nbM神经元的自发放电。
尽管nbM被认为在认知功能中起关键作用，但它可能参与伤害感受。此外，nbM似乎富含胆碱能自受体。
