Akiyama M, Shimizu H, Sugiura M, Nishikawa T
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Br J Dermatol. 1992 Dec;127(6):649-53. doi: 10.1111/j.1365-2133.1992.tb14882.x.
We investigated a 4-year-old Japanese boy with oculocutaneous albinism who had a solitary pigmented mole measuring 5 mm in diameter on his back. An electron microscopic tyrosine incubation test and a DOPA reaction test clearly demonstrated the presence of tyrosinase activity in the patient's hypopigmented skin. The presence of tyrosinase activity was confirmed by tests on hair bulb samples. Histopathological evidence showed that the mole was a typical compound cellular naevus with melanin pigmentation. Although no reports to date have focused on the relationship between pigmented naevi in albinism and tyrosinase activity, our findings suggest that the occurrence of pigmented naevi in an albino may indicate the presence of tyrosinase activity.
我们对一名患有眼皮肤白化病的4岁日本男孩进行了调查，他的背部有一个直径5毫米的孤立色素痣。电子显微镜酪氨酸孵育试验和多巴反应试验清楚地证明了患者色素减退皮肤中存在酪氨酸酶活性。通过对毛球样本的检测证实了酪氨酸酶活性的存在。组织病理学证据表明，该痣是一个典型的复合细胞痣，伴有黑色素沉着。尽管迄今为止尚无报道关注白化病中色素痣与酪氨酸酶活性之间的关系，但我们的研究结果表明，白化病患者出现色素痣可能表明存在酪氨酸酶活性。
