Kryzhanovskiĭ G N, Reshetniak V K, Kukushkin M L, Gorizontova M P, Smirnova V S
Biull Eksp Biol Med. 1992 Sep;114(9):229-31.
The effect of daily verapamil administration (5 mg/kg) on pain sensitivity, bioelectric activity of cerebral cortex and microcirculation was studied in rats with cut sciatic nerve. Verapamil untreated rats showed hyperalgesia, autotomies and hypersynchronic discharges in contralateral hemisphere, increased range of evoked potentials and disorders in microcirculatory system which evidence developing pain syndrome. Early introduction of verapamil after the nerve cut prevented the emergence of pain syndrome.
研究了每日给予维拉帕米（5毫克/千克）对坐骨神经切断大鼠痛觉敏感性、大脑皮层生物电活动和微循环的影响。未接受维拉帕米治疗的大鼠表现出痛觉过敏、自残行为以及对侧半球的超同步放电、诱发电位范围增加和微循环系统紊乱，这些都证明了疼痛综合征的发展。神经切断后早期引入维拉帕米可预防疼痛综合征的出现。
