Kukushkin M L, Smirnova V S, Gorizontova M P, Mironova I V, Zinkevich V A
Patol Fiziol Eksp Ter. 1993 Jul-Dec(4):16-9.
After cutting the sciatic nerve in rats, clofelin and propranolol were tested for effects on the development of the pain syndrome. It was found that in rats receiving neither clofelin nor propranolol, the cutting of the sciatic nerve resulted in hyperalgesia, autotomies, increased amplitude of evoked potentials in the contralateral somatosensory cortex during tissue stimulation of the paw with the nerve cut, as well as in impaired microcirculation and venular permeability in mesenteric vessels. A daily administration of clofelin or propranolol to the animals starting on the first day after nerve cutting was demonstrated to prevent disorders existing in control animals. The mechanisms of action of clofelin and propranolol which prevent the pain syndrome in the animals after the cutting of the sciatic nerve are discussed.
切断大鼠坐骨神经后，对氯非宁和普萘洛尔对疼痛综合征发展的影响进行了测试。结果发现，在既未接受对氯非宁也未接受普萘洛尔的大鼠中，切断坐骨神经会导致痛觉过敏、自残行为、在切断神经的爪子受到组织刺激时对侧体感皮层诱发电位幅度增加，以及肠系膜血管微循环和小静脉通透性受损。从切断神经后的第一天开始每天给动物施用对氯非宁或普萘洛尔，结果表明可预防对照动物中出现的紊乱。文中讨论了对氯非宁和普萘洛尔在大鼠坐骨神经切断后预防疼痛综合征的作用机制。
