Dukhanin A S, Bulaeva N N
Biull Eksp Biol Med. 1992 Sep;114(9):282-4.
A fluorescent probe was used to study hydrocortisone (10 microM) action on mitogen-stimulated free cytoplasmic calcium level in lymphocytes of patients with bronchial asthma. The patients were divided into two groups according to their sensitivity to glucocorticoid therapy. Hydrocortisone-specific calcium-blocking effect was absent in hormone-resistant patients. Lymphocytes of hormone-sensitive patients responded to hydrocortisone administration by a decline of mitogen-induced calcium level.
使用一种荧光探针研究氢化可的松（10微摩尔）对支气管哮喘患者淋巴细胞中丝裂原刺激的游离细胞质钙水平的作用。根据患者对糖皮质激素治疗的敏感性将其分为两组。激素抵抗型患者不存在氢化可的松特异性的钙阻断作用。激素敏感型患者的淋巴细胞在给予氢化可的松后，丝裂原诱导的钙水平下降。
