Prasolova N I, Gershteĭn E S, Smirnova K D, Chervinskaia T A
Klin Med (Mosk). 1990 Nov;68(11):28-30.
Quantitation of glucocorticoid receptors (GCR) and the study of their affinity for glucocorticosteroids (GCS) were made in peripheral blood lymphocytes of bronchial asthma (BA) patients in consideration of GCR treatment and serum levels of endogenous cortisol. It is stated that GCR of healthy controls and GCS-untreated patients outnumbered those of cortisol-dependent BA patients on hormone therapy. Following discontinuation of glucocorticoid drugs GCR count in cortisol-dependent BA tends to rise. Endogenous cortisol has no effect on GCR level estimated by 3H-triamcinolone acetonide.
考虑到糖皮质激素受体（GCR）治疗和内源性皮质醇的血清水平，对支气管哮喘（BA）患者外周血淋巴细胞中的糖皮质激素受体（GCR）进行了定量分析，并研究了它们对糖皮质激素（GCS）的亲和力。结果表明，健康对照者和未接受糖皮质激素治疗患者的GCR数量多于接受激素治疗的皮质醇依赖性BA患者。停用糖皮质激素药物后，皮质醇依赖性BA患者的GCR计数趋于上升。内源性皮质醇对用3H-曲安奈德评估的GCR水平没有影响。
